Glioblastoma (GBM), the deadliest form of brain cancer, long gift for localization issues. Chimeric antigen receptor (CAR) T cell immunotherapy has emerged as a potent strategy for treating cancer. IL-13-receptor-α2 (IL13Rα2), present in more than 75% of GBMs, has been recognized as an attractive candidate for anti-glioblastoma therapy. Here, we propose a multidisciplinary approach new for brain tumor targets using a combination of fluorescent, nanoparticle therapy and cell CAR T modified by the target-quadruple-mutant of IL13 (TQM-13) proved to have a binding of high affinity for IL13Rα2-expressing glioblastoma cell toxicity off low-target.

Azide-alkyne cycloaddition conjugation of nanoparticles onto the surface of T cells is allowed smoothly, selective, and clicking on high yield of nanoparticles. Nanoparticles clicked into the T cells were maintained for at least 8 days showed that a stable relationship and a promising window of time that is suitable for in vivo delivery.

T cell clicked with doxorubicin-loaded nanoparticles showed a higher cytotoxic effect in vitro compared to bare the T cells in vitro and in vivo T cells that express TQM-13 served as a freight shipment for nanoparticles and significantly increase the amount of nanoparticles reach the brain tumor compared with nanoparticles alone. This work represents a new platform to enable the delivery of nanoparticles for therapeutic and T cells of solid tumors.

High-affinity mutant <em>Interleukin</em>-<em>13</em> targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma.
High-affinity mutant Interleukin13 targeted CAR T cells enhance delivery of clickable biodegradable fluorescent nanoparticles to glioblastoma.

Matrix metalloproteinase- 13 , NF-kB p65 and interleukin -1β related to the severity of knee osteoarthritis.

Knee osteoarthritis (KOA) is a common disease, especially in older people. This study investigated the expression of matrix metalloproteinase-13 (MMP-13), NF-κBp65 and interleukin (IL) -lβ in synovial tissue of patients KOA and the role of MMP-13 and NF-κBp65 signaling pathway in the pathogenesis KOA.

A total of 100 patients were enrolled KOA in our hospital from December 2015 to December 2017 and classified as either mild group KOA (Outerbridge grade 1 and 2) or a group of severe KOA (Outerbridge grade 3 and 4). non-OA patients included as controls. synovial tissue of patients in both groups were collected to detect mRNA and protein expression of MMP-13, NF-κBp65 and IL-lβ. Synovial tissue sections were subjected to hematoxylin and eosin and immunohistochemistry (SP method). cartilage tissue was observed under light microscope after staining safranin O-fast green.

Analysis of quantitative reverse transcription-PCR and Western blot showed that the expression of MMP-13, NF-κBp65 and IL-lβ in mild and severe group was substantially deregulated compared with the control group (all P <0.05). A positive correlation between MMP-13 and NF-κBp65 expression in synovial tissue identified KOA (P <0.05). Immunohistochemistry revealed that the expression of MMP-13 and NF-κBp65 associated with the severity of KOA (MMP-13: heavy, 92.54%; moderate, 76.52%; control: 32.14%; and NF-κBp65: heavy, 85, 56%; moderate, 48.12%; control: 28.32%).

This evidence suggests that the severity of KOA associated with the expression of MMP-13 and NF-κBp65. NF-kB signaling pathway can be activated during the progression of OA, which could upregulate the expression of MMP-13 and IL-1β and accelerate damage to the articular cartilage.Repeated attacks muscle mitochondria exercise conditions to meet the increasing demand for energy-adaptive response associated with improved metabolic fitness.

Interleukin 12A (IL12A) Antibody

20-abx101511
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Interleukin 12A (IL12A) Antibody

20-abx129815
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Interleukin 12A (IL12A) Antibody

20-abx129967
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Interleukin 12A (IL12A) Antibody

20-abx130040
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Interleukin 12A (IL12A) Antibody

20-abx132017
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Interleukin 12A (IL12A) Antibody

20-abx132018
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Interleukin 12A (IL12A) Antibody

20-abx132019
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Interleukin 12A (IL12A) Antibody

20-abx173068
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Interleukin 12A (IL12A) Antibody

20-abx173069
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Interleukin 12A (IL12A) Antibody

20-abx173070
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Interleukin 12A (IL12A) Antibody

20-abx173071
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Interleukin 12A (IL12A) Antibody

20-abx173072
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Interleukin 12A (IL12A) Antibody

20-abx173073
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Interleukin 12A (IL12A) Antibody

20-abx173074
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Interleukin 12A (IL12A) Antibody

20-abx177084
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Interleukin 12A (IL12A) Antibody

20-abx177085
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Interleukin 12A (IL12A) Antibody

20-abx177086
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Interleukin 12A (IL12A) Antibody

20-abx177087
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Interleukin 12A (IL12A) Antibody

20-abx177088
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Interleukin 12A (IL12A) Antibody

20-abx177089
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Interleukin 12A (IL12A) Antibody

abx234218-100ug 100 ug
EUR 661.2

Interleukin 12A (IL12A) Antibody

20-abx121502
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Interleukin 12A (IL12A) Antibody

abx129815-100l 100 µl
EUR 262.5

Interleukin 12A (IL12A) Antibody

abx129815-1ml 1 ml
EUR 687.5

Interleukin 12A (IL12A) Antibody

abx129815-200l 200 µl
EUR 325

Interleukin 12A (IL12A) Antibody

abx129967-100l 100 µl
EUR 287.5

Interleukin 12A (IL12A) Antibody

abx129967-1ml 1 ml
EUR 812.5

Interleukin 12A (IL12A) Antibody

abx129967-200l 200 µl
EUR 362.5

Interleukin 12A (IL12A) Antibody

abx130040-100l 100 µl
EUR 262.5

Interleukin 12A (IL12A) Antibody

abx130040-1ml 1 ml
EUR 725

Interleukin 12A (IL12A) Antibody

abx130040-200l 200 µl
EUR 337.5

Interleukin 12A (IL12A) Antibody

abx132017-01mg 0.1 mg
EUR 262.5

Interleukin 12A (IL12A) Antibody

abx132018-01mg 0.1 mg
EUR 262.5

Interleukin 12A (IL12A) Antibody

abx132019-01mg 0.1 mg
EUR 262.5

Interleukin 12A (IL12A) Antibody

abx101511-100l 100 µl
EUR 250

Interleukin 12A (IL12A) Antibody

abx101511-1ml 1 ml
EUR 675

Interleukin 12A (IL12A) Antibody

abx101511-200l 200 µl
EUR 312.5

Interleukin 12A (IL12A) Antibody

abx177086-1096tests 10 × 96 tests
EUR 775

Interleukin 12A (IL12A) Antibody

abx177086-596tests 5 × 96 tests
EUR 350

Interleukin 12A (IL12A) Antibody

abx177086-96tests 96 tests
EUR 275

Interleukin 12A (IL12A) Antibody

abx234218-100g 100 µg
EUR 350

Interleukin 12A (IL12A) Antibody

abx173069-100l 100 µl
EUR 775

Interleukin 12A (IL12A) Antibody

abx173069-1ml 1 ml Ask for price

Interleukin 12A (IL12A) Antibody

abx173069-200l 200 µl Ask for price

Interleukin 12A (IL12A) Antibody

abx173070-100l 100 µl
EUR 812.5

Interleukin 12A (IL12A) Antibody

abx173070-1ml 1 ml Ask for price

Interleukin 12A (IL12A) Antibody

abx173070-200l 200 µl Ask for price

Interleukin 12A (IL12A) Antibody

abx173072-100l 100 µl
EUR 850

Interleukin 12A (IL12A) Antibody

abx173072-1ml 1 ml Ask for price

Interleukin 12A (IL12A) Antibody

abx173072-200l 200 µl Ask for price

Interleukin 12A (IL12A) Antibody

abx339129-100l 100 µl
EUR 350

Interleukin 12A (IL12A) Antibody

abx339129-50l 50 µl
EUR 250

Interleukin 12A (IL12A) Antibody

abx433653-100g 100 µg
EUR 387.5

Interleukin 12A (IL12A) Antibody

abx323723-100g 100 µg
EUR 250

Interleukin 12A (IL12A) Antibody

abx323723-50g 50 µg
EUR 187.5

Interleukin 12A (IL12A) Antibody

abx324096-100g 100 µg
EUR 250

Interleukin 12A (IL12A) Antibody

abx324096-50g 50 µg
EUR 187.5

Interleukin 12A (IL12A) Antibody

abx329683-100g 100 µg Ask for price

Interleukin 12A (IL12A) Antibody

abx329683-20g 20 µg
EUR 187.5

Interleukin 12A (IL12A) Antibody

abx329683-50g 50 µg
EUR 250

Interleukin 12A (IL12A) Antibody

abx334029-100g 100 µg
EUR 362.5

Interleukin 12A (IL12A) Antibody

abx334029-20g 20 µg
EUR 162.5

Interleukin 12A (IL12A) Antibody

abx334029-50g 50 µg
EUR 250

Active Interleukin 12A (IL12A)

APA059Hu01 10ug
EUR 324

Active Interleukin 12A (IL12A)

RPU59210-100ug 100ug
EUR 1069.2

Active Interleukin 12A (IL12A)

RPU59210-1mg 1mg
EUR 4738.5

Active Interleukin 12A (IL12A)

RPU59210-50ug 50ug
EUR 712.8

Interleukin 12A (IL12A) Antibody (HRP)

20-abx336162
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Interleukin 12A (IL12A) Antibody (HRP)

abx336162-100g 100 µg
EUR 362.5

Interleukin 12A (IL12A) Antibody (HRP)

abx336162-20g 20 µg
EUR 162.5

Interleukin 12A (IL12A) Antibody (HRP)

abx336162-50g 50 µg
EUR 250

Interleukin 12A (IL12A) Antibody (FITC)

20-abx336163
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Interleukin 12A (IL12A) Antibody Pair

20-abx370331
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Interleukin 12A (IL12A) Antibody (FITC)

20-abx273856
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Interleukin 12A (IL12A) Antibody (FITC)

abx273856-25mg 25 mg
EUR 950

Interleukin 12A (IL12A) Antibody (FITC)

abx273856-5mg 5 mg
EUR 400

Interleukin 12A (IL12A) Antibody Pair

abx370331-100g 100 µg
EUR 1212.5

Interleukin 12A (IL12A) Antibody (FITC)

abx336163-100g 100 µg
EUR 362.5

Interleukin 12A (IL12A) Antibody (FITC)

abx336163-20g 20 µg
EUR 162.5

Interleukin 12A (IL12A) Antibody (FITC)

abx336163-50g 50 µg
EUR 250

Interleukin 12A (IL12A) Antibody (Biotin)

20-abx274309
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Interleukin 12A (IL12A) Antibody (Biotin)

20-abx274463
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Interleukin 12A (IL12A) Antibody (Biotin)

20-abx336164
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Interleukin 12A (IL12A) Antibody (Biotin)

20-abx271906
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Interleukin 12A (IL12A) Antibody (Biotin)

abx271906-1ml 1 ml
EUR 737.5

Interleukin 12A (IL12A) Antibody (Biotin)

abx271906-200l 200 µl
EUR 337.5

Interleukin 12A (IL12A) Antibody (Biotin)

abx274309-1L 1 L
EUR 762.5

Interleukin 12A (IL12A) Antibody (Biotin)

abx274309-500ml 500 ml
EUR 337.5

Interleukin 12A (IL12A) Antibody (Biotin)

abx274463-100ml 100 ml
EUR 275

Interleukin 12A (IL12A) Antibody (Biotin)

abx336164-100g 100 µg
EUR 362.5

Interleukin 12A (IL12A) Antibody (Biotin)

abx336164-20g 20 µg
EUR 162.5

Interleukin 12A (IL12A) Antibody (Biotin)

abx336164-50g 50 µg
EUR 250

Interleukin 12A Blocking Peptide

AF5133-BP 1mg
EUR 234

Recombinant Interleukin 12A (IL12A)

RPU53379-100ug 100ug
EUR 552.2

Recombinant Interleukin 12A (IL12A)

RPU53379-1mg 1mg
EUR 2446.6

Recombinant Interleukin 12A (IL12A)

RPU53379-50ug 50ug
EUR 443.3

Recombinant Interleukin 12A (IL12A)

RPU53896-100ug 100ug
EUR 566.5

Recombinant Interleukin 12A (IL12A)

RPU53896-1mg 1mg
EUR 2511.6

Recombinant Interleukin 12A (IL12A)

RPU53896-50ug 50ug
EUR 455.4

Recombinant Interleukin 12A (IL12A)

RPU42219-100ug 100ug
EUR 554.4

Recombinant Interleukin 12A (IL12A)

RPU42219-1mg 1mg
EUR 2457

Recombinant Interleukin 12A (IL12A)

RPU42219-50ug 50ug
EUR 445.5

Recombinant Interleukin 12A (IL12A)

RPU57945-100ug 100ug
EUR 535.1

Recombinant Interleukin 12A (IL12A)

RPU57945-1mg 1mg
EUR 2483.5

Recombinant Interleukin 12A (IL12A)

RPU57945-50ug 50ug
EUR 415.9

Recombinant Interleukin 12A (IL12A)

RPU56643-100ug 100ug
EUR 470.4

Recombinant Interleukin 12A (IL12A)

RPU56643-1mg 1mg
EUR 2184

Recombinant Interleukin 12A (IL12A)

RPU56643-50ug 50ug
EUR 385

Recombinant Interleukin 12A (IL12A)

RPU54449-100ug 100ug
EUR 601.7

Recombinant Interleukin 12A (IL12A)

RPU54449-1mg 1mg
EUR 2665

Recombinant Interleukin 12A (IL12A)

RPU54449-50ug 50ug
EUR 482.9

Recombinant Interleukin 12A (IL12A)

RPA059Ca01 10ug
EUR 159

Recombinant Interleukin 12A (IL12A)

RPA059Hu01 10ug
EUR 180

Recombinant Interleukin 12A (IL12A)

4-RPA059Hu01
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Description: Recombinant Human Interleukin 12A expressed in: E.coli

Recombinant Interleukin 12A (IL12A)

RPA059Mu01 10ug
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Recombinant Interleukin 12A (IL12A)

4-RPA059Mu01
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Description: Recombinant Mouse Interleukin 12A expressed in: E.coli

Recombinant Interleukin 12A (IL12A)

RPA059Po01 10ug
EUR 195

Recombinant Interleukin 12A (IL12A)

4-RPA059Po01
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Description: Recombinant Pig Interleukin 12A expressed in: E.coli

Recombinant Interleukin 12A (IL12A)

RPA059Ra01 10ug
EUR 179

Recombinant Interleukin 12A (IL12A)

4-RPA059Ra01
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Description: Recombinant Rat Interleukin 12A expressed in: E.coli

Interleukin 12A (IL12A) Polyclonal Antibody

CAU28793-100ul 100ul
EUR 229.4

Interleukin 12A (IL12A) Polyclonal Antibody

CAU28793-200ul 200ul
EUR 287.3

Interleukin 12A (IL12A) Polyclonal Antibody

CAU28794-100ul 100ul
EUR 254.4

Interleukin 12A (IL12A) Polyclonal Antibody

CAU28794-200ul 200ul
EUR 317.5

Interleukin 12A (IL12A) Polyclonal Antibody

CAU28795-100ul 100ul
EUR 217.9

Interleukin 12A (IL12A) Polyclonal Antibody

CAU28795-200ul 200ul
EUR 272.2

Interleukin 12A (IL12A) Polyclonal Antibody

CAU28796-100ul 100ul
EUR 212.2

Interleukin 12A (IL12A) Polyclonal Antibody

CAU28796-200ul 200ul
EUR 265.4

Interleukin 12A (IL12A) Monoclonal Antibody

CAU30580-100ul 100ul
EUR 232.3

Interleukin 12A (IL12A) Monoclonal Antibody

CAU30580-200ul 200ul
EUR 290.6

Interleukin 12A (IL12A) Polyclonal Antibody

CAU30891-100ul 100ul
EUR 241.9

Interleukin 12A (IL12A) Polyclonal Antibody

CAU30891-200ul 200ul
EUR 302.4

Interleukin 12A (IL12A) Monoclonal Antibody

CAU29598-100ul 100ul
EUR 225.6

Interleukin 12A (IL12A) Monoclonal Antibody

CAU29598-200ul 200ul
EUR 282.2

Interleukin 12A (IL12A) Monoclonal Antibody

CAU29599-100ul 100ul
EUR 225.6

Interleukin 12A (IL12A) Monoclonal Antibody

CAU29599-200ul 200ul
EUR 282.2

Interleukin 12A (IL12A) Monoclonal Antibody

CAU29156-100ul 100ul
EUR 225.6

Interleukin 12A (IL12A) Monoclonal Antibody

CAU29156-200ul 200ul
EUR 282.2

Bovine Interleukin 12A ELISA Kit

IBOIL12AKT each
EUR 692
Description: Bovine Interleukin 12A ELISA Kit

Dog Interleukin 12A (IL12A) Protein

20-abx653954
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Cow Interleukin 12A (IL12A) Protein

20-abx653956
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Pig Interleukin 12A (IL12A) Protein

20-abx167532
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Rat Interleukin 12A (IL12A) Protein

20-abx167624
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  • 100 ug
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Porcine Interleukin 12A ELISA Kit

IPCIL12AKT each
EUR 692
Description: Porcine Interleukin 12A ELISA Kit

Chicken Interleukin 12A ELISA Kit

ICHIL12AKT each
EUR 624
Description: Chicken Interleukin 12A ELISA Kit

Pig Interleukin 12A (IL12A) Protein

abx167532-1ml 1 ml
EUR 437.5

Rat Interleukin 12A (IL12A) Protein

abx167624-1ml 1 ml
EUR 225

Cow Interleukin 12A (IL12A) Protein

abx653956-100tests 100 tests
EUR 2112.5

Goat Interleukin 12A (IL12A) Protein

20-abx653957
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  • 100 ug
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Horse Interleukin 12A (IL12A) Protein

20-abx653958
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  • 100 ug
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Human Interleukin 12A (IL12A) Protein

20-abx067440
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  • 100 ug
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Mouse Interleukin 12A (IL12A) Protein

20-abx167453
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We found that type 2 cytokine interleukin-13 (IL-13) is induced in the exercising muscle, where he orchestrates metabolic reprogramming is preserved glycogen in favor fatty acid oxidation and mitochondrial respiration.