Virus-Like Particle-Mediated Vaccination against Interleukin–13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis.
by Ronald
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Virus-like particle (VLP) based vaccination anti-infection prophylaxis has been established in clinical use. Although validated in a proof-of-concept clinical trials in humans, there is no VLP-based vaccine therapy against self-proteins to modulate chronic disease has not been licensed.
This review summarizes the scientific advances recently, identifying interleukin-13 as a very good candidate to validate the concept of anti-cytokine vaccination. Based on numerous clinical studies, the long-term elimination of IL-13 is not expected to trigger the associated target serious side effects and tend to be more secure than the combined target the IL-4 / IL-13. Furthermore, the recent results published on a large scale trial to confirm that deletion of IL-13 is highly effective in atopic dermatitis, a very common condition, and eosinophilic esophagitis.
Clearly different mode of action polyclonal vaccine responses are discussed in detail, suggesting that vaccination anti-IL-13 has the potential exceeds a monoclonal antibody-based approach. Finally, recent data have identified a subset of T helper follicular cells dependent on IL-13 that selectively trigger the accumulation of large IgE in response anaphylactoid allergens. Thus, IL-13 vaccination prophylaxis may have broad applications in a number of allergic conditions.
Virus-Like Particle-Mediated Vaccination against Interleukin–13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis.
Neuroprotective modulation of microglia effector function following priming with interleukin 4 and 13 :
the current limitations in understanding the mode-of-action them. In recent years the old theory for dual polarization properties of microglia phenotype toward pro or anti-inflammatory has been very challenging. Furthermore, the explanation microglia exposed ontogenesis intrinsic differences between microglia and peripheral myeloid cells, thus further emphasize the need for re-evaluation of the specific behavior of microglia activation, especially in an environment of inflamed central nervous system (CNS).
This review summarizes the recent literature on the critical in vitro and in vivo murine microglia response to immune-modulatory cytokine interleukin 4 (IL4) and interleukin 13 (IL13), ie those driving the so-called anti-inflammatory phenotype. Here we highlight some of the important factors that could influence the outcome of experiments and / or interpretation of in vitro and in vivo studies to evaluate this microglia phenotypical and functional properties of the IL4 / IL13 treatment.
Finally, the relevance of the current therapy of microglia activation IL4 / IL13-induced in both acute and chronic CNS disorders discussed.Osteoarthritis (OA) is a degenerative joint disease that seriously affects the quality of life of patients. Irisin has been reported to regulate bone metabolism through an autocrine mechanism of cellular and play a protective role in OA rats. In this study, the SW1353 chondrosarcoma cell lines were treated with interleukin (IL) -1β and irisin.
This study evaluated the viability of the cells, the level of expression of collagen II (Col II) and matrix metalloproteinase-13 (MMP-13), and the activity of the Wnt / β-catenin and NF-kB signaling pathways in cells treated SW1353. These results suggest that IL-1β can decrease the expression of Col II and increase MMP-13 expression in both mRNA and protein levels, and also activate the Wnt / β-catenin and NF-kB signaling pathway in SW1353 cells.
Description: Interleukin-17B Human Recombinant produced in E.Coli is a homodimeric, non-disulfide-linked polypeptide chain containing a total of 322 amino acids (2 chains of 161aa) and having a molecular mass of 36.5kDa. The IL-17B is purified by proprietary chromatographic techniques.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Rat Interleukin 17B (IL17B)Serum, plasma and other biological fluids
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 17B (IL17B) in samples from serum, plasma or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Rat Interleukin 17B (IL17B) in samples from serum, plasma or other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Interleukin 17B (IL17B) in samples from Serum, plasma and other biological fluids. with no significant corss-reactivity with analogues from other species.
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat IL17B. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat IL17B. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat IL17B, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat IL17B in the samples is then determined by comparing the OD of the samples to the standard curve.
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat IL17B. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat IL17B. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat IL17B, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat IL17B in the samples is then determined by comparing the OD of the samples to the standard curve.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Interleukin 17B (IL17B)Serum, plasma and other biological fluids
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Mouse Interleukin 17B (IL17B)Serum, plasma and other biological fluids
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 17B (IL17B) in samples from serum, plasma or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Human Interleukin 17B (IL17B) in samples from serum, plasma or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 17B (IL17B) in samples from serum, plasma or other biological fluids.
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Interleukin 17B (IL17B) in samples from serum, plasma or other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Interleukin 17B (IL17B) in samples from Serum, plasma and other biological fluids. with no significant corss-reactivity with analogues from other species.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Interleukin 17B (IL17B) in serum, plasma and other biological fluids.
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Interleukin 17B (IL17B) in samples from Serum, plasma and other biological fluids. with no significant corss-reactivity with analogues from other species.
Instead, irisin identified to reverse the effects of IL-1β to IL-1β-induced SW1353 cells. These results indicate that treatment irisin may have a cartilage-protective role model SW1353 cell-induced IL-1β.
