Hyperglycemia is a well-known indicator of stroke prognosis, and a third of non-diabetic patients develop hyperglycemia postischemic during the acute phase of stroke; This relates to the relatively poor prognosis, high mortality, and impaired neurological recovery. Interleukin-13 (IL-13), a member of the family of Th2 cytokines, which are involved in the regulation of immune responses and metabolism of glucose.

Thus, we investigated the mechanism of postischemic hyperglycemia and the role of IL-13 by using a rat model of permanent middle cerebral artery occlusion (MCAO). Our results show that hyperglycemia and hyperinsulinemia postischemic accompanied by an increase in HOMA-IR, elevated hepatic gluconeogenesis and reduced insulin signaling.

A shift in the direction of the inflammatory response was evident with the results of the elevated proinflammatory cytokines and increased expression of negative regulatory proteins, indicating an ongoing vicious cycle of insulin-resistant hyperglycemia induced inflammation. IL-13 treatment counteracted proinflammatory state and eliminate a vicious circle through increased stat-6 and STAT3, which mediated immune and metabolic pathways respectively;

This effect resolved pathological changes previously described postischemic hyperglycemia and reduced infarct size in rat MCAO. Our findings show the importance of Th1-Th2 balance in peripheral glucose metabolism affected by acute ischemic stroke, which gives a new perspective to the prevention and control of hyperglycemia postischemic.

<em>Interleukin</em>-<em>13</em> ameliorates postischemic hepatic gluconeogenesis and hyperglycemia in rat model of stroke
Interleukin13 ameliorates postischemic hepatic gluconeogenesis and hyperglycemia in rat model of stroke

interleukin – 13 receptor subunit alpha-2 is the target of the progesterone receptor and koaktivator steroid receptor-1 in rat uterus

Endometrium, composed of epithelial and stromal cell compartment, closely regulated by ovarian steroid hormones estrogen (E2) and progesterone (P4) during early pregnancy. Through the progesterone receptor (PGR), steroid receptor coactivators, and other transcription coregulators, progesterone inhibits the E2-induced cell proliferation and induce differentiation of stroma cells in a process called decidualizing to promote the acceptance of the endometrium.

Although the interleukin-13 receptor subunit alpha-2 (Il13ra2) is expressed in human and mouse endometrium, the potential role of steroid hormones in the regulation of endometrial not yet been thoroughly researched. In this study, we employ PGR KO mice (PRKO) and koaktivator steroid receptor-1 knockout mice (SRC-1 – / -) to Il13ra2 expression profile in murine endometrium and decisive role in the transcriptional regulator of hormone responsive Il13ra2 expression. In addition, we utilized decidualizing-inducing cocktail steroidogenic established and based siRNA knockdown of IL13RA2 to determine the importance decidualizing IL13RA2 in primary human endometrial stromal cells.

Our findings indicate that Il13ra2 stated in sub-epithelial endometrial stromal murine ovarian steroid hormones in response to and during early pregnancy by PGR- and SRC-1-dependent. In addition, we demonstrated that knockdown of IL13RA2 before in vitro human endometrial stromal cells decidualizing main portion decidualizing compromise full response. We conclude that Il13ra2 is a downstream target of progesterone through PGR and SRC-1 and plays a role in mediating the action of stromal ovarian steroid hormones.

1730 8 SNAP-SEAL 8 OZ

1730-8 100/pk
EUR 74
Description: Disposable Plastic; Plastic Containers

Interleukin 8 (IL8) Antibody

abx018002-100ug 100 ug
EUR 342
  • Shipped within 5-10 working days.

Interleukin 8 (IL8) Antibody

abx216289-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

Interleukin 8 (IL8) Antibody

abx036426-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Anti-Interleukin-8 antibody

STJ16101158 100 µg
EUR 451

Anti-IL6/ Interleukin 6 Antibody Clone IL6-Q3, Unconjugated-100ug

QDX34-100ug 100ug
EUR 403

Anti-IL6/ Interleukin 6 Antibody Clone IL6-Q2, Unconjugated-100ug

QDX35-100ug 100ug
EUR 403

Anti-IL6/ Interleukin 6 Antibody Clone IL6-Q1, Unconjugated-100ug

QDX36-100ug 100ug
EUR 403

Anti-IL6/ Interleukin 6 Antibody Clone IL6-Q8, Unconjugated-100ug

QDX37-100ug 100ug
EUR 403

Interleukin 8 / IL8 (CXCL8) Antibody

abx200558-100ug 100 ug
EUR 453
  • Shipped within 2-3 weeks.

Individual Reaction Mix 8

G065-8 200 reactions
EUR 167

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Human IL-8 Recombinant Protein

R00423-8 5ug/vial
EUR 259
Description: Interleukin-8 (IL-8), also known as CXCL8, is an ELR-positive CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. Human IL-8 Recombinant Protein is purified interleukin-8 produced in yeast.

Recombinant Mouse KLK-8/ Kallikrein-8 Protein, His, Yeast-100ug

QP9804-ye-100ug 100ug
EUR 571

Interleukin-1 Family Member 8 (IL1F8) Antibody

abx234240-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Interleukin-1 Family Member 8 (IL1F8) Antibody

abx234241-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Recombinant HSV HSV-8 M Protein, GST, E.coli-100ug

QP12349-100ug 100ug
EUR 218

Recombinant Pig IL-8/ CXCL8 Protein, Untagged, E.coli-100ug

QP5522-100ug 100ug
EUR 509

Recombinant Human Caspase-8 Protein, His, E.coli-100ug

QP8921-ec-100ug 100ug
EUR 408

Recombinant Human IL6/ Interleukin 6 Protein, Native, Human-100ug

QDX53-100ug 100ug
EUR 615

Recombinant Human IL7/ Interleukin 7 Protein, Untagged, E.coli-100ug

QP1180-100ug 100ug
EUR 708

Recombinant Mouse IL6/ Interleukin-6 Protein, Untagged, E.coli-100ug

QP1487-100ug 100ug
EUR 608

Recombinant Human IL6/ Interleukin-6 Protein, Untagged, E.coli-100ug

QP5235-100ug 100ug
EUR 490

Recombinant Mouse IL7/ Interleukin 7 Protein, Untagged, E.coli-100ug

QP5401-100ug 100ug
EUR 708

Recombinant Mouse IL19/ Interleukin-19 Protein, Untagged, E.coli-100ug

QP5483-100ug 100ug
EUR 237

Recombinant Rat IL6/ Interleukin-6 Protein, Untagged, E.coli-100ug

QP5501-100ug 100ug
EUR 708

IL-8, Interleukin-8, monkey

RC222-19 5ug
EUR 104.38
  • Product category: Proteins/Recombinant Proteins/Cytokines

Anti-Fibronectin Antibody Clone 2755-8., Unconjugated-100ug

2335-MSM3-P1 100ug
EUR 428

Anti-Cytokeratin 8 Antibody Clone H1, Unconjugated-100ug

3856-MSM1-P1 100ug
EUR 428

Anti-Cytokeratin 8 Antibody Clone B22.1, Unconjugated-100ug

3856-MSM10-P1 100ug
EUR 428

Anti-Cytokeratin 8 Antibody Clone SPM538, Unconjugated-100ug

3856-MSM1X-P1 100ug
EUR 428

Anti-Cytokeratin 8 Antibody Clone TS1, Unconjugated-100ug

3856-MSM4-P1 100ug
EUR 428

Anti-Cytokeratin 8 Antibody Clone SPM192, Unconjugated-100ug

3856-MSM4X-P1 100ug
EUR 428

Anti-Cytokeratin 8 Antibody Clone K8.8, Unconjugated-100ug

3856-MSM7-P1 100ug
EUR 428

Anti-Biotin Antibody Clone Hyb-8, Unconjugated-100ug

MSM1-400-P1 100ug
EUR 428

Anti-CD314 Antibody [CX5], Unconjugated-100ug

QAB100-100ug 100ug
EUR 182

Anti-CD4 Antibody [OKT4], Unconjugated-100ug

QAB11-100ug 100ug
EUR 123

Anti-CD8a Antibody [Hit8a], Unconjugated-100ug

QAB20-100ug 100ug
EUR 149

Anti-CD11c Antibody [N418], Unconjugated-100ug

QAB23-100ug 100ug
EUR 157

Anti-CD11c Antibody [3.9], Unconjugated-100ug

QAB24-100ug 100ug
EUR 141

Anti-CD11b Antibody [ICRF44], Unconjugated-100ug

QAB25-100ug 100ug
EUR 141

Anti-CD19 Antibody [1D3], Unconjugated-100ug

QAB28-100ug 100ug
EUR 141

Anti-CD3 Antibody [17A2], Unconjugated-100ug

QAB3-100ug 100ug
EUR 141

Anti-CD25 Antibody [PC61.5], Unconjugated-100ug

QAB34-100ug 100ug
EUR 123

Anti-CD25 Antibody [BC96], Unconjugated-100ug

QAB35-100ug 100ug
EUR 141

Anti-CD27 Antibody [O323], Unconjugated-100ug

QAB36-100ug 100ug
EUR 141

Anti-CD28 Antibody [CD28.2], Unconjugated-100ug

QAB37-100ug 100ug
EUR 141

Anti-CD45.1 Antibody [A20], Unconjugated-100ug

QAB42-100ug 100ug
EUR 157

Anti-CD45.2 Antibody [104], Unconjugated-100ug

QAB43-100ug 100ug
EUR 141

Anti-CD45RO Antibody [UCHL1], Unconjugated-100ug

QAB44-100ug 100ug
EUR 141

Anti-CD45RA Antibody [HI100], Unconjugated-100ug

QAB45-100ug 100ug
EUR 141

Anti-CD45 Antibody [HI30], Unconjugated-100ug

QAB46-100ug 100ug
EUR 141

Anti-CD3 Antibody [OKT3], Unconjugated-100ug

QAB5-100ug 100ug
EUR 149

Anti-CD3 Antibody [UCHT1], Unconjugated-100ug

QAB6-100ug 100ug
EUR 141

Anti-CD8a Antibody [2.43], Unconjugated-100ug

QAB61-100ug 100ug
EUR 149

Anti-CD3 Antibody [Hit3a], Unconjugated-100ug

QAB7-100ug 100ug
EUR 141

Anti-KLRG1 Antibody [2F1], Unconjugated-100ug

QAB74-100ug 100ug
EUR 141

Anti-CD161 Antibody [PK136], Unconjugated-100ug

QAB78-100ug 100ug
EUR 141

Anti-CD4 Antibody [GK1.5], Unconjugated-100ug

QAB8-100ug 100ug
EUR 123

Anti-CD32 Antibody [2.4G2], Unconjugated-100ug

QAB87-100ug 100ug
EUR 141

Anti-CD28 Antibody [37.51], Unconjugated-100ug

QAB99-100ug 100ug
EUR 149

Recombinant Human GDF-8/ Myostatin/ MSTN Protein, Untagged, E.coli-100ug

QP5265-100ug 100ug
EUR 708

Interleukin-8 Protein

20-abx261534
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

Interleukin 8 Antibody

AF5146 200ul
EUR 304
Description: Interleukin 8 Antibody detects endogenous levels of total Interleukin 8.

Interleukin?8 Antibody

ABF5146 100 ug
EUR 438

Recombinant Human Interleukin-26 Protein, His, Yeast-100ug

QP9904-ye-100ug 100ug
EUR 480

Recombinant Xenopus Protein Wnt-8 Protein, His, Yeast-100ug

QP9601-ye-100ug 100ug
EUR 788

Recombinant Human IL-8/ CXCL8 Protein, Untagged, E.coli-100ug

QP10315-ec-100ug 100ug
EUR 807

Recombinant Macaque IL-8/ CXCL8 Protein, Untagged, E.coli-100ug

QP1557-ec-100ug 100ug
EUR 1178

Recombinant Dog IL-8/ CXCL8 Protein, GST, E.coli-100ug

QP6227-ec-100ug 100ug
EUR 707

Recombinant Dog IL-8/ CXCL8 Protein, His, Mammal-100ug

QP6227-ma-100ug 100ug
EUR 1178

Recombinant Dog IL-8/ CXCL8 Protein, His, Yeast-100ug

QP6227-ye-100ug 100ug
EUR 788

Recombinant Human Cytokeratin 8 Protein, His-SUMO, E.coli-100ug

QP6284-ec-100ug 100ug
EUR 408

Mouse Anti Sheep Interleukin-8 Monoclonal Antibody

CABT-48526MS 0.25 mg
EUR 892

Rabbit Anti Human Interleukin-8 Polyclonal Antibody

CPBT-65418RH 0.1 mg
EUR 881

Rabbit Anti Sheep Interleukin-8 Polyclonal Antibody

CPBT-65420RS 0.1 ml
EUR 741

Mouse Monoclonal Anti-Human Interleukin-8 IgG

AB-11110 100 ug
EUR 347

Recombinant Mouse Interleukin-2/ IL-2 Protein, Untagged, E.coli-100ug

QP1489-100ug 100ug
EUR 490

Recombinant Rat Interleukin-2/ IL-2 Protein, Untagged, E.coli-100ug

QP1546-100ug 100ug
EUR 599

Recombinant Human Interleukin-32/ IL-32 Protein, Untagged, E.coli-100ug

QP5209-100ug 100ug
EUR 708

Recombinant Human Interleukin-21/ IL-21 Protein, Untagged, E.coli-100ug

QP5394-100ug 100ug
EUR 708

Recombinant other Y. Enterocolitica (O:8) YopM Protein, His, E.coli-100ug

QP13974-100ug 100ug
EUR 962

Anti-c-Myc Antibody [9E10], Unconjugated-100ug

QAB102-100ug 100ug
EUR 216

Anti-CD4 Antibody [RPA-T4], Unconjugated-100ug

QAB12-100ug 100ug
EUR 123

Anti-CD8a Antibody [53-6.7], Unconjugated-100ug

QAB16-100ug 100ug
EUR 131

Anti-CD8a Antibody [RPA-T8], Unconjugated-100ug

QAB19-100ug 100ug
EUR 149

Anti-CD3e Antibody [145-2C11], Unconjugated-100ug

QAB2-100ug 100ug
EUR 123

Anti-CD45 Antibody [30-F11], Unconjugated-100ug

QAB40-100ug 100ug
EUR 149

Anti-CD80 Antibody [16-10A1], Unconjugated-100ug

QAB50-100ug 100ug
EUR 182

Anti-CD86 Antibody [GL-1], Unconjugated-100ug

QAB51-100ug 100ug
EUR 157

Anti-CD161 Antibody [HP-3G10], Unconjugated-100ug

QAB60-100ug 100ug
EUR 157

Anti-IL-4 Antibody [11B11], Unconjugated-100ug

QAB81-100ug 100ug
EUR 149

Anti-FCER1A Antibody [MAR-1], Unconjugated-100ug

QAB91-100ug 100ug
EUR 182

8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit

DLR-8-OHdG-Ge-48T 48T
EUR 469
  • Should the 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of 8-Hydroxydeoxyguanosine (8-OHdG) in samples from serum, plasma or other biological fluids.

8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit

DLR-8-OHdG-Ge-96T 96T
EUR 608
  • Should the 8-Hydroxydeoxyguanosine (8-OHdG) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement.
Description: A competitive inhibition quantitative ELISA assay kit for detection of 8-Hydroxydeoxyguanosine (8-OHdG) in samples from serum, plasma or other biological fluids.

0.5-10UL 8-CHANNEL, DIGITAL PIPETTOR

AP-8-10 1/pk
EUR 425
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

20-200UL 8-CHANNEL, DIGITAL PIPETTOR

AP-8-200 1/pk
EUR 425
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

50-300UL 8-CHANNEL, DIGITAL PIPETTOR

AP-8-300 1/pk
EUR 425
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller

5-50UL 8-CHANNEL, DIGITAL PIPETTOR

AP-8-50 1/pk
EUR 425
Description: Corning and Axygen Liquid Handling Equipment; Axypet Pipettors and Motopet Pipet Controller


Lung function did not significantly differ between the three groups before treatment. After treatment, the time to relief of symptoms was significantly shorter in the GG group than that in the other two groups. forced expiratory volume in one second expiratory flow and percent predicted peak was also significantly better in the GG group compared to the other two groups.