Hyperglycemia is a well-known indicator of stroke prognosis, and a third of non-diabetic patients develop hyperglycemia postischemic during the acute phase of stroke; This relates to the relatively poor prognosis, high mortality, and impaired neurological recovery. Interleukin-13 (IL-13), a member of the family of Th2 cytokines, which are involved in the regulation of immune responses and metabolism of glucose.

Thus, we investigated the mechanism of postischemic hyperglycemia and the role of IL-13 by using a rat model of permanent middle cerebral artery occlusion (MCAO). Our results show that hyperglycemia and hyperinsulinemia postischemic accompanied by an increase in HOMA-IR, elevated hepatic gluconeogenesis and reduced insulin signaling.

A shift in the direction of the inflammatory response was evident with the results of the elevated proinflammatory cytokines and increased expression of negative regulatory proteins, indicating an ongoing vicious cycle of insulin-resistant hyperglycemia induced inflammation. IL-13 treatment counteracted proinflammatory state and eliminate a vicious circle through increased stat-6 and STAT3, which mediated immune and metabolic pathways respectively;

This effect resolved pathological changes previously described postischemic hyperglycemia and reduced infarct size in rat MCAO. Our findings show the importance of Th1-Th2 balance in peripheral glucose metabolism affected by acute ischemic stroke, which gives a new perspective to the prevention and control of hyperglycemia postischemic.

<em>Interleukin</em>-<em>13</em> ameliorates postischemic hepatic gluconeogenesis and hyperglycemia in rat model of stroke
Interleukin13 ameliorates postischemic hepatic gluconeogenesis and hyperglycemia in rat model of stroke

interleukin – 13 receptor subunit alpha-2 is the target of the progesterone receptor and koaktivator steroid receptor-1 in rat uterus

Endometrium, composed of epithelial and stromal cell compartment, closely regulated by ovarian steroid hormones estrogen (E2) and progesterone (P4) during early pregnancy. Through the progesterone receptor (PGR), steroid receptor coactivators, and other transcription coregulators, progesterone inhibits the E2-induced cell proliferation and induce differentiation of stroma cells in a process called decidualizing to promote the acceptance of the endometrium.

Although the interleukin-13 receptor subunit alpha-2 (Il13ra2) is expressed in human and mouse endometrium, the potential role of steroid hormones in the regulation of endometrial not yet been thoroughly researched. In this study, we employ PGR KO mice (PRKO) and koaktivator steroid receptor-1 knockout mice (SRC-1 – / -) to Il13ra2 expression profile in murine endometrium and decisive role in the transcriptional regulator of hormone responsive Il13ra2 expression. In addition, we utilized decidualizing-inducing cocktail steroidogenic established and based siRNA knockdown of IL13RA2 to determine the importance decidualizing IL13RA2 in primary human endometrial stromal cells.

Our findings indicate that Il13ra2 stated in sub-epithelial endometrial stromal murine ovarian steroid hormones in response to and during early pregnancy by PGR- and SRC-1-dependent. In addition, we demonstrated that knockdown of IL13RA2 before in vitro human endometrial stromal cells decidualizing main portion decidualizing compromise full response. We conclude that Il13ra2 is a downstream target of progesterone through PGR and SRC-1 and plays a role in mediating the action of stromal ovarian steroid hormones.

OPRB00186-100UG - Interleukin-8 Protein

OPRB00186-100UG 100ug
EUR 823

Rabbit anti Pig Interleukin-8

MBS225032-01mg 0.1mg
EUR 645

Rabbit anti Pig Interleukin-8

MBS225032-5x01mg 5x0.1mg
EUR 2730

MOUSE ANTI SHEEP INTERLEUKIN-8

MBS212255-025mg 0.25mg
EUR 590

MOUSE ANTI SHEEP INTERLEUKIN-8

MBS212255-5x025mg 5x0.25mg
EUR 2475

Goat anti Rabbit Interleukin-8

MBS225357-01mg 0.1mg
EUR 645

Goat anti Rabbit Interleukin-8

MBS225357-5x01mg 5x0.1mg
EUR 2730

Mouse Anti Sheep Interleukin-8

MBS225680-01mg 0.1mg
EUR 425

Mouse Anti Sheep Interleukin-8

MBS225680-5x01mg 5x0.1mg
EUR 1745

Mouse anti Human Interleukin-8

MBS226199-01mg 0.1mg
EUR 355

Mouse anti Human Interleukin-8

MBS226199-5x01mg 5x0.1mg
EUR 1425

MOUSE ANTI HUMAN INTERLEUKIN-8

MBS212027-05mg 0.5mg
EUR 1175

MOUSE ANTI HUMAN INTERLEUKIN-8

MBS212027-5x05mg 5x0.5mg
EUR 5110

Mouse Anti Human Interleukin-8

MBS140012-05mg 0.5mg
EUR 440

Mouse Anti Human Interleukin-8

MBS140012-1mg 1mg
EUR 600

Mouse Anti Human Interleukin-8

MBS140012-5x1mg 5x1mg
EUR 2375

RABBIT ANTI HUMAN INTERLEUKIN-8

MBS221719-01mg 0.1mg
EUR 635

RABBIT ANTI HUMAN INTERLEUKIN-8

MBS221719-5x01mg 5x0.1mg
EUR 2695

RABBIT ANTI SHEEP INTERLEUKIN-8

MBS223143-01mL 0.1mL
EUR 710

RABBIT ANTI SHEEP INTERLEUKIN-8

MBS223143-5x01mL 5x0.1mL
EUR 3030

OPCA01259-100UG - Recombinant dog Interleukin-8

OPCA01259-100UG 100ug
EUR 668

OPCA00136-100UG - Recombinant dog Interleukin-8

OPCA00136-100UG 100ug
EUR 586

OPCA00137-100UG - Recombinant sheep Interleukin-8

OPCA00137-100UG 100ug
EUR 586

MOUSE ANTI HUMAN INTERLEUKIN-8:FITC

MBS214540-100Tests 100Tests
EUR 435

MOUSE ANTI HUMAN INTERLEUKIN-8:FITC

MBS214540-5x100Tests 5x100Tests
EUR 1785

Rabbit anti Pig Interleukin-8: Biotin

MBS225033-005mg 0.05mg
EUR 645

Rabbit anti Pig Interleukin-8: Biotin

MBS225033-5x005mg 5x0.05mg
EUR 2730

Goat anti Rabbit Interleukin-8: Biotin

MBS225358-005mg 0.05mg
EUR 645

Goat anti Rabbit Interleukin-8: Biotin

MBS225358-5x005mg 5x0.05mg
EUR 2730

Mouse anti Human Interleukin-8:Biotin

MBS226198-01mg 0.1mg
EUR 435

Mouse anti Human Interleukin-8:Biotin

MBS226198-5x01mg 5x0.1mg
EUR 1785

RABBIT ANTI HUMAN INTERLEUKIN-8:Biotin

MBS220205-005mg 0.05mg
EUR 635

RABBIT ANTI HUMAN INTERLEUKIN-8:Biotin

MBS220205-5x005mg 5x0.05mg
EUR 2680

Interleukin-8

AP84418 1mg
EUR 2640

Interleukin-8

AP84457 1mg
EUR 2640

Interleukin-8

AP84711 1mg
EUR 2640

Interleukin-8

AP78367 1mg
EUR 2640

Interleukin-8

AP78368 1mg
EUR 2640

INTERLEUKIN-8

MBS225884-01mg 0.1mg
EUR 645

INTERLEUKIN-8

MBS225884-5x01mg 5x0.1mg
EUR 2730

Interleukin-8 (IL-8), Antibody

GWB-F1FEAE 0.25 mg Ask for price

Interleukin-8 (IL-8), Antibody

GWB-A6A6C2 0.25 mg Ask for price

Interleukin-8 Antibody

GWB-6A112B 0.5 mg Ask for price

Interleukin-8 Antibody

GWB-A0A76C 0.1 mg Ask for price

Interleukin-8 (IL-8)

MBS343081-001mg 0.01mg
EUR 275

Interleukin-8 (IL-8)

MBS343081-01mg 0.1mg
EUR 710

Interleukin-8 (IL-8)

MBS343081-1mg 1mg
EUR 3220

Interleukin-8 (IL-8)

MBS343081-5x1mg 5x1mg
EUR 14325

Interleukin-8 (IL-8)

MBS590014-192Wells 192Wells
EUR 995

Interleukin-8 (IL-8)

MBS590014-3x192Wells 3x192Wells
EUR 2315

Interleukin-8 (IL-8)

MBS590014-96Wells 96Wells
EUR 675

Interleukin-8 (IL-8)

MBS592466-01mg 0.1mg
EUR 420

Interleukin-8 (IL-8)

MBS592466-05mg 0.5mg
EUR 545

Interleukin-8 (IL-8)

MBS592466-5x05mg 5x0.5mg
EUR 2205

Interleukin-8 (IL-8)

THP-0255 1 vial
EUR 3198.4
Description: Protein

Interleukin 8

MBS596224-1mg 1mg
EUR 425

Interleukin 8

MBS596224-2mg 2mg
EUR 700

Interleukin 8

MBS596224-5mg 5mg
EUR 1505

Interleukin?8 Antibody

ABF5146 100 ug
EUR 525.6

Interleukin 8 Antibody

E18-5146-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

Interleukin 8 Antibody

E18-5146-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Interleukin 8 Antibody

MBS9601319-01mL 0.1mL
EUR 260

Interleukin 8 Antibody

MBS9601319-02mL 0.2mL
EUR 305

Interleukin 8 Antibody

MBS9601319-5x02mL 5x0.2mL
EUR 1220

Interleukin 8 Antibody

MBS8511777-005mg 0.05mg
EUR 235

Interleukin 8 Antibody

MBS8511777-01mg 0.1mg
EUR 305

Interleukin 8 Antibody

MBS8511777-01mLAF405M 0.1mL(AF405M)
EUR 465

Interleukin 8 Antibody

MBS8511777-01mLAF546 0.1mL(AF546)
EUR 465

Interleukin 8 Antibody

MBS8511777-01mLAF750 0.1mL(AF750)
EUR 465

Il1f8 (untagged) - Mouse interleukin 1 family, member 8 (Il1f8), (10ug)

MC210986 10 µg Ask for price

Anti- Interleukin-8 receptor type B Antibody

GWB-32D924 0.05 ml Ask for price

Anti- Interleukin-8 receptor type B Antibody

GWB-9B4704 0.05 ml Ask for price

Recombinant Sheep Interleukin-8 Protein, His, E.coli-100ug

QP6228-ec-100ug 100ug
EUR 848.4

Human Interleukin-8 (IL-8) Antibody

13102-05011 150 ug
EUR 175

Il1f8 (GFP-tagged) - Mouse interleukin 1 family member 8 (Il1f8), (10ug)

MG220215 10 µg Ask for price

Mouse Monoclonal Anti-Human Interleukin-8 IgG

AB-11110 100 ug
EUR 416.4

Mouse Anti Sheep Interleukin-8 Monoclonal Antibody

CABT-48526MS 0.25 mg
EUR 667.8
Description: Mouse

Human Interleukin-8 Antibody

33486-05111 150 ug
EUR 215

Interleukin-8 (CXCL8) Antibody

abx402319-100g 100 µg
EUR 287.5

Sheep Interleukin-8 Antibody

GWB-213280 0.25 mg Ask for price

Sheep Interleukin-8 Antibody

GWB-Q00722 0.1 ml Ask for price

Interleukin 8 (IL-8) Antibody Pair

abx378032-96tests 96 tests
EUR 525

Rabbit Anti Human Interleukin-8 Polyclonal Antibody

CPBT-65418RH 0.1 mg
EUR 659.4
Description: Rabbit

Rabbit Anti Sheep Interleukin-8 Polyclonal Antibody

CPBT-65420RS 0.1 ml
EUR 546
Description: Rabbit

Rabbit anti-dog Interleukin-8 polyclonal Antibody

MBS1489187-005mg 0.05mg
EUR 190

Rabbit anti-dog Interleukin-8 polyclonal Antibody

MBS1489187-01mg 0.1mg
EUR 270

Rabbit anti-dog Interleukin-8 polyclonal Antibody

MBS1489187-5x01mg 5x0.1mg
EUR 1205

Interleukin 8 (IL-8) (AP)

MBS6121816-01mL 0.1(mL
EUR 730

Interleukin 8 (IL-8) (AP)

MBS6121816-5x01mL 5x0.1mL
EUR 3135

Interleukin 8 (IL-8) (PE)

MBS6122056-01mL 0.1(mL
EUR 730

Interleukin 8 (IL-8) (PE)

MBS6122056-5x01mL 5x0.1mL
EUR 3135

Interleukin 8 (IL-8) (AP)

MBS6482864-01mL 0.1mL
EUR 635

Interleukin 8 (IL-8) (AP)

MBS6482864-5x01mL 5x0.1mL
EUR 2700

Interleukin 8 (IL-8) (PE)

MBS6482874-01mL 0.1mL
EUR 635

Interleukin 8 (IL-8) (PE)

MBS6482874-5x01mL 5x0.1mL
EUR 2700

Interleukin 8 (IL-8) (AP)

MBS6482875-01mL 0.1mL
EUR 1100

Interleukin 8 (IL-8) (AP)

MBS6482875-5x01mL 5x0.1mL
EUR 4810

Interleukin 8 (IL-8) (PE)

MBS6482885-01mL 0.1mL
EUR 1100

Interleukin 8 (IL-8) (PE)

MBS6482885-5x01mL 5x0.1mL
EUR 4810

IL-8, Interleukin-8, monkey

RC222-19 5ug
EUR 125.26

INTERLEUKIN-8: Biotin

MBS225885-005mg 0.05mg
EUR 645

INTERLEUKIN-8: Biotin

MBS225885-5x005mg 5x0.05mg
EUR 2730

Interleukin-8 Antibody (Biotin)

GWB-93F063 0.05 mg Ask for price

Interleukin 8 (IL-8) (APC)

MBS6121864-01mL 0.1(mL
EUR 730

Interleukin 8 (IL-8) (APC)

MBS6121864-5x01mL 5x0.1mL
EUR 3135

Interleukin 8 (IL-8) (HRP)

MBS6122008-01mL 0.1(mL
EUR 730

Interleukin 8 (IL-8) (HRP)

MBS6122008-5x01mL 5x0.1mL
EUR 3135

Interleukin 8 (IL-8) (APC)

MBS6482865-01mL 0.1mL
EUR 635

Interleukin 8 (IL-8) (APC)

MBS6482865-5x01mL 5x0.1mL
EUR 2700

Interleukin 8 (IL-8) (HRP)

MBS6482868-01mL 0.1mL
EUR 635

Interleukin 8 (IL-8) (HRP)

MBS6482868-5x01mL 5x0.1mL
EUR 2700

Interleukin 8 (IL-8) (APC)

MBS6482876-01mL 0.1mL
EUR 1100

Interleukin 8 (IL-8) (APC)

MBS6482876-5x01mL 5x0.1mL
EUR 4810

Interleukin 8 (IL-8) (HRP)

MBS6482879-01mL 0.1mL
EUR 1100

Interleukin 8 (IL-8) (HRP)

MBS6482879-5x01mL 5x0.1mL
EUR 4810

Interleukin-8 Protein

abx261534-100g 100 µg
EUR 3550

Interleukin-8 Protein

abx261534-10g 10 µg
EUR 325

Interleukin-8 Protein

20-abx261534
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  • 5 ug
  • 20 ug
  • 1 mg

Interleukin-8 Protein

abx261534-2g 2 µg
EUR 225

Rabbit anti-human Interleukin-8 polyclonal Antibody

MBS7006367-005mg 0.05mg
EUR 190

Rabbit anti-human Interleukin-8 polyclonal Antibody

MBS7006367-01mg 0.1mg
EUR 270

Rabbit anti-human Interleukin-8 polyclonal Antibody

MBS7006367-5x01mg 5x0.1mg
EUR 1205

Interleukin 8 (IL8) Antibody

20-abx177199
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  • 10 ug
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  • 1 mg

Interleukin 8 (IL8) Antibody

abx177199-1096tests 10 × 96 tests
EUR 625

Interleukin 8 (IL8) Antibody

abx177199-596tests 5 × 96 tests
EUR 300

Interleukin 8 (IL8) Antibody

abx177199-96tests 96 tests
EUR 237.5

Interleukin 8 (IL8) Antibody

20-abx177201
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  • 200 ug
  • 1 mg

Interleukin 8 (IL8) Antibody

abx173191-100l 100 µl
EUR 287.5

Interleukin 8 (IL8) Antibody

20-abx173191
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  • 20 ug
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  • 1 mg

Interleukin 8 (IL8) Antibody

abx173191-1ml 1 ml
EUR 850

Interleukin 8 (IL8) Antibody

abx173191-200l 200 µl
EUR 375

Interleukin 8 (IL8) Antibody

abx100960-100l 100 µl
EUR 212.5

Interleukin 8 (IL8) Antibody

20-abx100960
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  • 10 ug
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  • 1 mg

Interleukin 8 (IL8) Antibody

abx100960-1ml 1 ml
EUR 475

Interleukin 8 (IL8) Antibody

abx100960-200l 200 µl
EUR 250

Interleukin 8 (IL8) Antibody

abx100961-100l 100 µl
EUR 250

Interleukin 8 (IL8) Antibody

20-abx100961
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  • 10 ug
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  • 1 mg

Interleukin 8 (IL8) Antibody

abx100961-1ml 1 ml
EUR 687.5

Interleukin 8 (IL8) Antibody

abx100961-200l 200 µl
EUR 325

Interleukin 8 (IL8) Antibody

abx100962-100l 100 µl
EUR 250

Interleukin 8 (IL8) Antibody

20-abx100962
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  • 10 ug
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  • 1 mg

Interleukin 8 (IL8) Antibody

abx100962-1ml 1 ml
EUR 687.5

Interleukin 8 (IL8) Antibody

abx100962-200l 200 µl
EUR 325

Interleukin 8 (IL8) Antibody

abx100963-100l 100 µl
EUR 237.5

Interleukin 8 (IL8) Antibody

20-abx100963
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  • 20 ug
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  • 100 ug
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  • 1 mg

Interleukin 8 (IL8) Antibody

abx100963-1ml 1 ml
EUR 625

Interleukin 8 (IL8) Antibody

abx100963-200l 200 µl
EUR 300

Interleukin 8 (IL8) Antibody

abx100964-100l 100 µl
EUR 237.5

Interleukin 8 (IL8) Antibody

20-abx100964
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  • 20 ug
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  • 1 mg


Lung function did not significantly differ between the three groups before treatment. After treatment, the time to relief of symptoms was significantly shorter in the GG group than that in the other two groups. forced expiratory volume in one second expiratory flow and percent predicted peak was also significantly better in the GG group compared to the other two groups.