Hyperglycemia is a well-known indicator of stroke prognosis, and a third of non-diabetic patients develop hyperglycemia postischemic during the acute phase of stroke; This relates to the relatively poor prognosis, high mortality, and impaired neurological recovery. Interleukin-13 (IL-13), a member of the family of Th2 cytokines, which are involved in the regulation of immune responses and metabolism of glucose.
Thus, we investigated the mechanism of postischemic hyperglycemia and the role of IL-13 by using a rat model of permanent middle cerebral artery occlusion (MCAO). Our results show that hyperglycemia and hyperinsulinemia postischemic accompanied by an increase in HOMA-IR, elevated hepatic gluconeogenesis and reduced insulin signaling.
A shift in the direction of the inflammatory response was evident with the results of the elevated proinflammatory cytokines and increased expression of negative regulatory proteins, indicating an ongoing vicious cycle of insulin-resistant hyperglycemia induced inflammation. IL-13 treatment counteracted proinflammatory state and eliminate a vicious circle through increased stat-6 and STAT3, which mediated immune and metabolic pathways respectively;
This effect resolved pathological changes previously described postischemic hyperglycemia and reduced infarct size in rat MCAO. Our findings show the importance of Th1-Th2 balance in peripheral glucose metabolism affected by acute ischemic stroke, which gives a new perspective to the prevention and control of hyperglycemia postischemic.
interleukin – 13 receptor subunit alpha-2 is the target of the progesterone receptor and koaktivator steroid receptor-1 in rat uterus
Endometrium, composed of epithelial and stromal cell compartment, closely regulated by ovarian steroid hormones estrogen (E2) and progesterone (P4) during early pregnancy. Through the progesterone receptor (PGR), steroid receptor coactivators, and other transcription coregulators, progesterone inhibits the E2-induced cell proliferation and induce differentiation of stroma cells in a process called decidualizing to promote the acceptance of the endometrium.
Although the interleukin-13 receptor subunit alpha-2 (Il13ra2) is expressed in human and mouse endometrium, the potential role of steroid hormones in the regulation of endometrial not yet been thoroughly researched. In this study, we employ PGR KO mice (PRKO) and koaktivator steroid receptor-1 knockout mice (SRC-1 – / -) to Il13ra2 expression profile in murine endometrium and decisive role in the transcriptional regulator of hormone responsive Il13ra2 expression. In addition, we utilized decidualizing-inducing cocktail steroidogenic established and based siRNA knockdown of IL13RA2 to determine the importance decidualizing IL13RA2 in primary human endometrial stromal cells.
Our findings indicate that Il13ra2 stated in sub-epithelial endometrial stromal murine ovarian steroid hormones in response to and during early pregnancy by PGR- and SRC-1-dependent. In addition, we demonstrated that knockdown of IL13RA2 before in vitro human endometrial stromal cells decidualizing main portion decidualizing compromise full response. We conclude that Il13ra2 is a downstream target of progesterone through PGR and SRC-1 and plays a role in mediating the action of stromal ovarian steroid hormones.
OPRB00186-100UG - Interleukin-8 Protein |
|||
OPRB00186-100UG | Aviva Systems Biology | 100ug | EUR 823 |
Interleukin-8 |
|||
AP78367 | SAB | 1mg | EUR 2640 |
Interleukin-8 |
|||
AP78368 | SAB | 1mg | EUR 2640 |
Interleukin-8 |
|||
AP84418 | SAB | 1mg | EUR 2640 |
Interleukin-8 |
|||
AP84457 | SAB | 1mg | EUR 2640 |
Interleukin-8 |
|||
AP84711 | SAB | 1mg | EUR 2640 |
Interleukin-8 (IL-8), Antibody |
|||
GWB-A6A6C2 | GenWay Biotech | 0.25 mg | Ask for price |
Interleukin-8 (IL-8), Antibody |
|||
GWB-F1FEAE | GenWay Biotech | 0.25 mg | Ask for price |
Interleukin-8 Antibody |
|||
GWB-A0A76C | GenWay Biotech | 0.1 mg | Ask for price |
Interleukin-8 Antibody |
|||
GWB-6A112B | GenWay Biotech | 0.5 mg | Ask for price |
OPCA00136-100UG - Recombinant dog Interleukin-8 |
|||
OPCA00136-100UG | Aviva Systems Biology | 100ug | EUR 586 |
OPCA01259-100UG - Recombinant dog Interleukin-8 |
|||
OPCA01259-100UG | Aviva Systems Biology | 100ug | EUR 668 |
OPCA00137-100UG - Recombinant sheep Interleukin-8 |
|||
OPCA00137-100UG | Aviva Systems Biology | 100ug | EUR 586 |
Interleukin 8 Antibody |
|||
E18-5146-1 | EnoGene | 50μg/50μl | EUR 145 |
Description: Available in various conjugation types. |
Interleukin 8 Antibody |
|||
E18-5146-2 | EnoGene | 100μg/100μl | EUR 225 |
Description: Available in various conjugation types. |
Interleukin?8 Antibody |
|||
ABF5146 | Lifescience Market | 100 ug | EUR 525.6 |
Anti- Interleukin-8 receptor type B Antibody |
|||
GWB-32D924 | GenWay Biotech | 0.05 ml | Ask for price |
Anti- Interleukin-8 receptor type B Antibody |
|||
GWB-9B4704 | GenWay Biotech | 0.05 ml | Ask for price |
Human Interleukin-8 (IL-8) Antibody |
|||
13102-05011 | AssayPro | 150 ug | EUR 175 |
IL-8, Interleukin-8, monkey |
|||
RC222-19 | Bio Basic | 5ug | EUR 125.26 |
Human Interleukin-8 Antibody |
|||
33486-05111 | AssayPro | 150 ug | EUR 215 |
Sheep Interleukin-8 Antibody |
|||
GWB-213280 | GenWay Biotech | 0.25 mg | Ask for price |
Sheep Interleukin-8 Antibody |
|||
GWB-Q00722 | GenWay Biotech | 0.1 ml | Ask for price |
Interleukin-8 (CXCL8) Antibody |
|||
abx402319-100g | Abbexa | 100 µg | EUR 287.5 |
Interleukin 8 (IL-8) Antibody Pair |
|||
abx378032-96tests | Abbexa | 96 tests | EUR 525 |
Interleukin-8 Protein |
|||
20-abx261534 | Abbexa |
|
|
Interleukin-8 Protein |
|||
abx261534-100g | Abbexa | 100 µg | EUR 3550 |
Interleukin-8 Protein |
|||
abx261534-10g | Abbexa | 10 µg | EUR 325 |
Interleukin-8 Protein |
|||
abx261534-2g | Abbexa | 2 µg | EUR 225 |
Interleukin-8 Antibody (Biotin) |
|||
GWB-93F063 | GenWay Biotech | 0.05 mg | Ask for price |
Interleukin 8 (IL8) Antibody |
|||
20-abx100960 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx100961 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx100962 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx100963 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx100964 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx100965 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx100966 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx100967 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx100969 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx100970 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx100971 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx100972 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx131832 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx131833 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx131834 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx131835 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx131836 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx131837 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx131838 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx131839 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx131840 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx137023 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
abx036426-100ug | Abbexa | 100 ug | EUR 469.2 |
Interleukin 8 (IL8) Antibody |
|||
abx018002-100ug | Abbexa | 100 ug | EUR 410.4 |
Interleukin 8 (IL8) Antibody |
|||
abx020956-05mg | Abbexa | 0.5 mg | EUR 1296 |
Interleukin 8 (IL8) Antibody |
|||
20-abx009111 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx270103 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx270152 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx270200 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx270201 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx173191 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
abx216289-100ug | Abbexa | 100 ug | EUR 526.8 |
Interleukin 8 (IL8) Antibody |
|||
20-abx177199 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
20-abx177201 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
abx100960-100l | Abbexa | 100 µl | EUR 212.5 |
Interleukin 8 (IL8) Antibody |
|||
abx100960-1ml | Abbexa | 1 ml | EUR 475 |
Interleukin 8 (IL8) Antibody |
|||
abx100960-200l | Abbexa | 200 µl | EUR 250 |
Interleukin 8 (IL8) Antibody |
|||
abx100961-100l | Abbexa | 100 µl | EUR 250 |
Interleukin 8 (IL8) Antibody |
|||
abx100961-1ml | Abbexa | 1 ml | EUR 687.5 |
Interleukin 8 (IL8) Antibody |
|||
abx100961-200l | Abbexa | 200 µl | EUR 325 |
Interleukin 8 (IL8) Antibody |
|||
abx100962-100l | Abbexa | 100 µl | EUR 250 |
Interleukin 8 (IL8) Antibody |
|||
abx100962-1ml | Abbexa | 1 ml | EUR 687.5 |
Interleukin 8 (IL8) Antibody |
|||
abx100962-200l | Abbexa | 200 µl | EUR 325 |
Interleukin 8 (IL8) Antibody |
|||
abx100963-100l | Abbexa | 100 µl | EUR 237.5 |
Interleukin 8 (IL8) Antibody |
|||
abx100963-1ml | Abbexa | 1 ml | EUR 625 |
Interleukin 8 (IL8) Antibody |
|||
abx100963-200l | Abbexa | 200 µl | EUR 300 |
Interleukin 8 (IL8) Antibody |
|||
abx100964-100l | Abbexa | 100 µl | EUR 237.5 |
Interleukin 8 (IL8) Antibody |
|||
abx100964-1ml | Abbexa | 1 ml | EUR 625 |
Interleukin 8 (IL8) Antibody |
|||
abx100964-200l | Abbexa | 200 µl | EUR 300 |
Interleukin 8 (IL8) Antibody |
|||
abx100965-100l | Abbexa | 100 µl | EUR 250 |
Interleukin 8 (IL8) Antibody |
|||
abx100965-1ml | Abbexa | 1 ml | EUR 650 |
Interleukin 8 (IL8) Antibody |
|||
abx100965-200l | Abbexa | 200 µl | EUR 312.5 |
Interleukin 8 (IL8) Antibody |
|||
abx100966-100l | Abbexa | 100 µl | EUR 262.5 |
Interleukin 8 (IL8) Antibody |
|||
abx100966-1ml | Abbexa | 1 ml | EUR 687.5 |
Interleukin 8 (IL8) Antibody |
|||
abx100966-200l | Abbexa | 200 µl | EUR 325 |
Interleukin 8 (IL8) Antibody |
|||
abx100967-100l | Abbexa | 100 µl | EUR 262.5 |
Interleukin 8 (IL8) Antibody |
|||
abx100967-1ml | Abbexa | 1 ml | EUR 712.5 |
Interleukin 8 (IL8) Antibody |
|||
abx100967-200l | Abbexa | 200 µl | EUR 325 |
Interleukin 8 (IL8) Antibody |
|||
abx100969-100l | Abbexa | 100 µl | EUR 275 |
Interleukin 8 (IL8) Antibody |
|||
abx100969-1ml | Abbexa | 1 ml | EUR 775 |
Interleukin 8 (IL8) Antibody |
|||
abx100969-200l | Abbexa | 200 µl | EUR 350 |
Interleukin 8 (IL8) Antibody |
|||
abx100971-100l | Abbexa | 100 µl | EUR 287.5 |
Interleukin 8 (IL8) Antibody |
|||
abx100971-1ml | Abbexa | 1 ml | EUR 825 |
Interleukin 8 (IL8) Antibody |
|||
abx100971-200l | Abbexa | 200 µl | EUR 362.5 |
Interleukin 8 (IL8) Antibody |
|||
abx100972-100l | Abbexa | 100 µl | EUR 300 |
Interleukin 8 (IL8) Antibody |
|||
abx100972-1ml | Abbexa | 1 ml | EUR 875 |
Interleukin 8 (IL8) Antibody |
|||
abx100972-200l | Abbexa | 200 µl | EUR 375 |
Interleukin 8 (IL8) Antibody |
|||
abx173191-100l | Abbexa | 100 µl | EUR 287.5 |
Interleukin 8 (IL8) Antibody |
|||
abx173191-1ml | Abbexa | 1 ml | EUR 850 |
Interleukin 8 (IL8) Antibody |
|||
abx173191-200l | Abbexa | 200 µl | EUR 375 |
Interleukin 8 (IL8) Antibody |
|||
abx177199-1096tests | Abbexa | 10 × 96 tests | EUR 625 |
Interleukin 8 (IL8) Antibody |
|||
abx177199-596tests | Abbexa | 5 × 96 tests | EUR 300 |
Interleukin 8 (IL8) Antibody |
|||
abx036426-100g | Abbexa | 100 µg | EUR 337.5 |
Interleukin 8 (IL8) Antibody |
|||
abx018002-1mg | Abbexa | 1 mg | EUR 262.5 |
Interleukin 8 (IL8) Antibody |
|||
abx270152-1ml | Abbexa | 1 ml | EUR 425 |
Interleukin 8 (IL8) Antibody |
|||
abx270152-200l | Abbexa | 200 µl | EUR 300 |
Interleukin 8 (IL8) Antibody |
|||
abx131832-100g | Abbexa | 100 µg | EUR 875 |
Interleukin 8 (IL8) Antibody |
|||
abx131832-20g | Abbexa | 20 µg | EUR 375 |
Interleukin 8 (IL8) Antibody |
|||
abx131832-5g | Abbexa | 5 µg | EUR 300 |
Interleukin 8 (IL8) Antibody |
|||
abx131833-100g | Abbexa | 100 µg | EUR 812.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131833-20g | Abbexa | 20 µg | EUR 362.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131833-5g | Abbexa | 5 µg | EUR 287.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131834-100g | Abbexa | 100 µg | EUR 762.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131834-20g | Abbexa | 20 µg | EUR 337.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131834-5g | Abbexa | 5 µg | EUR 275 |
Interleukin 8 (IL8) Antibody |
|||
abx131835-100g | Abbexa | 100 µg | EUR 775 |
Interleukin 8 (IL8) Antibody |
|||
abx131835-20g | Abbexa | 20 µg | EUR 350 |
Interleukin 8 (IL8) Antibody |
|||
abx131835-5g | Abbexa | 5 µg | EUR 275 |
Interleukin 8 (IL8) Antibody |
|||
abx131836-100g | Abbexa | 100 µg | EUR 812.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131836-20g | Abbexa | 20 µg | EUR 362.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131836-5g | Abbexa | 5 µg | EUR 287.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131837-100g | Abbexa | 100 µg | EUR 812.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131837-20g | Abbexa | 20 µg | EUR 362.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131837-5g | Abbexa | 5 µg | EUR 287.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131838-100g | Abbexa | 100 µg | EUR 625 |
Interleukin 8 (IL8) Antibody |
|||
abx131838-20g | Abbexa | 20 µg | EUR 300 |
Interleukin 8 (IL8) Antibody |
|||
abx131838-5g | Abbexa | 5 µg | EUR 237.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131839-100g | Abbexa | 100 µg | EUR 762.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131839-20g | Abbexa | 20 µg | EUR 337.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131839-5g | Abbexa | 5 µg | EUR 275 |
Interleukin 8 (IL8) Antibody |
|||
abx131840-100g | Abbexa | 100 µg | EUR 762.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131840-20g | Abbexa | 20 µg | EUR 337.5 |
Interleukin 8 (IL8) Antibody |
|||
abx131840-5g | Abbexa | 5 µg | EUR 275 |
Interleukin 8 (IL8) Antibody |
|||
abx137023-01mg | Abbexa | 0.1 mg | EUR 487.5 |
Interleukin 8 (IL8) Antibody |
|||
abx177199-96tests | Abbexa | 96 tests | EUR 237.5 |
Fish Interleukin 8-IL-8 |
|||
QY-E160089 | Qayee Biotechnology | 96T | EUR 580 |
Mouse Monoclonal Anti-Human Interleukin-8 IgG |
|||
AB-11110 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Mouse Anti Sheep Interleukin-8 Monoclonal Antibody |
|||
CABT-48526MS | Creative Diagnostics | 0.25 mg | EUR 1070.4 |
Rabbit Anti Human Interleukin-8 Polyclonal Antibody |
|||
CPBT-65418RH | Creative Diagnostics | 0.1 mg | EUR 1057.2 |
Rabbit Anti Sheep Interleukin-8 Polyclonal Antibody |
|||
CPBT-65420RS | Creative Diagnostics | 0.1 ml | EUR 889.2 |
Interleukin-8 Polyclonal Antibody |
|||
42502 | SAB | 100μg | EUR 390 |
Interleukin-8 Polyclonal Antibody |
|||
42502-100ul | SAB | 100ul | EUR 399.6 |
Interleukin-8 (IL-8) (72a.a) Human |
|||
GWB-3997EC | GenWay Biotech | 0.025 mg | Ask for price |
Dog Interleukin-8 (IL8) |
|||
1-CSB-YP011671DO | Cusabio |
|
|
Description: Recombinant Dog Interleukin-8(IL8) expressed in Yeast |
Dog Interleukin-8 (IL8) |
|||
1-CSB-EP011671DO | Cusabio |
|
|
Description: Recombinant Dog Interleukin-8(IL8) expressed in E.coli |
Dog Interleukin-8 (IL8) |
|||
1-CSB-MP011671DO | Cusabio |
|
|
Description: Recombinant Dog Interleukin-8(IL8) expressed in Mammalian cell |
Recombinant Sheep Interleukin-8 Protein, His, E.coli-100ug |
|||
QP6228-ec-100ug | EnQuireBio | 100ug | EUR 848.4 |
Sheep Interleukin-8 (IL8) |
|||
1-CSB-EP011671SH | Cusabio |
|
|
Description: Recombinant Sheep Interleukin-8(IL8) expressed in E.coli |
Interleukin-8 ELISA Kit |
|||
GWB-C28770 | GenWay Biotech | 96 TESTS | Ask for price |
Lung function did not significantly differ between the three groups before treatment. After treatment, the time to relief of symptoms was significantly shorter in the GG group than that in the other two groups. forced expiratory volume in one second expiratory flow and percent predicted peak was also significantly better in the GG group compared to the other two groups.