Hyperglycemia is a well-known indicator of stroke prognosis, and a third of non-diabetic patients develop hyperglycemia postischemic during the acute phase of stroke; This relates to the relatively poor prognosis, high mortality, and impaired neurological recovery. Interleukin-13 (IL-13), a member of the family of Th2 cytokines, which are involved in the regulation of immune responses and metabolism of glucose.
Thus, we investigated the mechanism of postischemic hyperglycemia and the role of IL-13 by using a rat model of permanent middle cerebral artery occlusion (MCAO). Our results show that hyperglycemia and hyperinsulinemia postischemic accompanied by an increase in HOMA-IR, elevated hepatic gluconeogenesis and reduced insulin signaling.
A shift in the direction of the inflammatory response was evident with the results of the elevated proinflammatory cytokines and increased expression of negative regulatory proteins, indicating an ongoing vicious cycle of insulin-resistant hyperglycemia induced inflammation. IL-13 treatment counteracted proinflammatory state and eliminate a vicious circle through increased stat-6 and STAT3, which mediated immune and metabolic pathways respectively;
This effect resolved pathological changes previously described postischemic hyperglycemia and reduced infarct size in rat MCAO. Our findings show the importance of Th1-Th2 balance in peripheral glucose metabolism affected by acute ischemic stroke, which gives a new perspective to the prevention and control of hyperglycemia postischemic.
interleukin – 13 receptor subunit alpha-2 is the target of the progesterone receptor and koaktivator steroid receptor-1 in rat uterus
Endometrium, composed of epithelial and stromal cell compartment, closely regulated by ovarian steroid hormones estrogen (E2) and progesterone (P4) during early pregnancy. Through the progesterone receptor (PGR), steroid receptor coactivators, and other transcription coregulators, progesterone inhibits the E2-induced cell proliferation and induce differentiation of stroma cells in a process called decidualizing to promote the acceptance of the endometrium.
Although the interleukin-13 receptor subunit alpha-2 (Il13ra2) is expressed in human and mouse endometrium, the potential role of steroid hormones in the regulation of endometrial not yet been thoroughly researched. In this study, we employ PGR KO mice (PRKO) and koaktivator steroid receptor-1 knockout mice (SRC-1 – / -) to Il13ra2 expression profile in murine endometrium and decisive role in the transcriptional regulator of hormone responsive Il13ra2 expression. In addition, we utilized decidualizing-inducing cocktail steroidogenic established and based siRNA knockdown of IL13RA2 to determine the importance decidualizing IL13RA2 in primary human endometrial stromal cells.
Our findings indicate that Il13ra2 stated in sub-epithelial endometrial stromal murine ovarian steroid hormones in response to and during early pregnancy by PGR- and SRC-1-dependent. In addition, we demonstrated that knockdown of IL13RA2 before in vitro human endometrial stromal cells decidualizing main portion decidualizing compromise full response. We conclude that Il13ra2 is a downstream target of progesterone through PGR and SRC-1 and plays a role in mediating the action of stromal ovarian steroid hormones.
OPRB00186-100UG - Interleukin-8 Protein |
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| OPRB00186-100UG | Aviva Systems Biology | 100ug | EUR 823 |
Rabbit anti Pig Interleukin-8 |
|||
| MBS225032-01mg | MyBiosource | 0.1mg | EUR 645 |
Rabbit anti Pig Interleukin-8 |
|||
| MBS225032-5x01mg | MyBiosource | 5x0.1mg | EUR 2730 |
Mouse Anti Human Interleukin-8 |
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| MBS140012-05mg | MyBiosource | 0.5mg | EUR 440 |
Mouse Anti Human Interleukin-8 |
|||
| MBS140012-1mg | MyBiosource | 1mg | EUR 600 |
Mouse Anti Human Interleukin-8 |
|||
| MBS140012-5x1mg | MyBiosource | 5x1mg | EUR 2375 |
MOUSE ANTI SHEEP INTERLEUKIN-8 |
|||
| MBS212255-025mg | MyBiosource | 0.25mg | EUR 590 |
MOUSE ANTI SHEEP INTERLEUKIN-8 |
|||
| MBS212255-5x025mg | MyBiosource | 5x0.25mg | EUR 2475 |
MOUSE ANTI HUMAN INTERLEUKIN-8 |
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| MBS212027-05mg | MyBiosource | 0.5mg | EUR 1175 |
MOUSE ANTI HUMAN INTERLEUKIN-8 |
|||
| MBS212027-5x05mg | MyBiosource | 5x0.5mg | EUR 5110 |
Mouse anti Human Interleukin-8 |
|||
| MBS226199-01mg | MyBiosource | 0.1mg | EUR 355 |
Mouse anti Human Interleukin-8 |
|||
| MBS226199-5x01mg | MyBiosource | 5x0.1mg | EUR 1425 |
Goat anti Rabbit Interleukin-8 |
|||
| MBS225357-01mg | MyBiosource | 0.1mg | EUR 645 |
Goat anti Rabbit Interleukin-8 |
|||
| MBS225357-5x01mg | MyBiosource | 5x0.1mg | EUR 2730 |
Mouse Anti Sheep Interleukin-8 |
|||
| MBS225680-01mg | MyBiosource | 0.1mg | EUR 425 |
Mouse Anti Sheep Interleukin-8 |
|||
| MBS225680-5x01mg | MyBiosource | 5x0.1mg | EUR 1745 |
RABBIT ANTI HUMAN INTERLEUKIN-8 |
|||
| MBS221719-01mg | MyBiosource | 0.1mg | EUR 635 |
RABBIT ANTI HUMAN INTERLEUKIN-8 |
|||
| MBS221719-5x01mg | MyBiosource | 5x0.1mg | EUR 2695 |
RABBIT ANTI SHEEP INTERLEUKIN-8 |
|||
| MBS223143-01mL | MyBiosource | 0.1mL | EUR 710 |
RABBIT ANTI SHEEP INTERLEUKIN-8 |
|||
| MBS223143-5x01mL | MyBiosource | 5x0.1mL | EUR 3030 |
OPCA00136-100UG - Recombinant dog Interleukin-8 |
|||
| OPCA00136-100UG | Aviva Systems Biology | 100ug | EUR 586 |
OPCA01259-100UG - Recombinant dog Interleukin-8 |
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| OPCA01259-100UG | Aviva Systems Biology | 100ug | EUR 668 |
OPCA00137-100UG - Recombinant sheep Interleukin-8 |
|||
| OPCA00137-100UG | Aviva Systems Biology | 100ug | EUR 586 |
MOUSE ANTI HUMAN INTERLEUKIN-8:FITC |
|||
| MBS214540-100Tests | MyBiosource | 100Tests | EUR 435 |
MOUSE ANTI HUMAN INTERLEUKIN-8:FITC |
|||
| MBS214540-5x100Tests | MyBiosource | 5x100Tests | EUR 1785 |
Rabbit anti Pig Interleukin-8: Biotin |
|||
| MBS225033-005mg | MyBiosource | 0.05mg | EUR 645 |
Rabbit anti Pig Interleukin-8: Biotin |
|||
| MBS225033-5x005mg | MyBiosource | 5x0.05mg | EUR 2730 |
Mouse anti Human Interleukin-8:Biotin |
|||
| MBS226198-01mg | MyBiosource | 0.1mg | EUR 435 |
Mouse anti Human Interleukin-8:Biotin |
|||
| MBS226198-5x01mg | MyBiosource | 5x0.1mg | EUR 1785 |
Goat anti Rabbit Interleukin-8: Biotin |
|||
| MBS225358-005mg | MyBiosource | 0.05mg | EUR 645 |
Goat anti Rabbit Interleukin-8: Biotin |
|||
| MBS225358-5x005mg | MyBiosource | 5x0.05mg | EUR 2730 |
RABBIT ANTI HUMAN INTERLEUKIN-8:Biotin |
|||
| MBS220205-005mg | MyBiosource | 0.05mg | EUR 635 |
RABBIT ANTI HUMAN INTERLEUKIN-8:Biotin |
|||
| MBS220205-5x005mg | MyBiosource | 5x0.05mg | EUR 2680 |
Interleukin-8 |
|||
| AP78367 | SAB | 1mg | EUR 2640 |
Interleukin-8 |
|||
| AP78368 | SAB | 1mg | EUR 2640 |
Interleukin-8 |
|||
| AP84418 | SAB | 1mg | EUR 2640 |
Interleukin-8 |
|||
| AP84457 | SAB | 1mg | EUR 2640 |
Interleukin-8 |
|||
| AP84711 | SAB | 1mg | EUR 2640 |
INTERLEUKIN-8 |
|||
| MBS225884-01mg | MyBiosource | 0.1mg | EUR 645 |
INTERLEUKIN-8 |
|||
| MBS225884-5x01mg | MyBiosource | 5x0.1mg | EUR 2730 |
Interleukin-8 (IL-8), Antibody |
|||
| GWB-A6A6C2 | GenWay Biotech | 0.25 mg | Ask for price |
Interleukin-8 (IL-8), Antibody |
|||
| GWB-F1FEAE | GenWay Biotech | 0.25 mg | Ask for price |
Interleukin-8 Antibody |
|||
| GWB-A0A76C | GenWay Biotech | 0.1 mg | Ask for price |
Interleukin-8 Antibody |
|||
| GWB-6A112B | GenWay Biotech | 0.5 mg | Ask for price |
Interleukin-8 (IL-8) |
|||
| MBS590014-192Wells | MyBiosource | 192Wells | EUR 995 |
Interleukin-8 (IL-8) |
|||
| MBS590014-3x192Wells | MyBiosource | 3x192Wells | EUR 2315 |
Interleukin-8 (IL-8) |
|||
| MBS590014-96Wells | MyBiosource | 96Wells | EUR 675 |
Interleukin-8 (IL-8) |
|||
| MBS592466-01mg | MyBiosource | 0.1mg | EUR 420 |
Interleukin-8 (IL-8) |
|||
| MBS592466-05mg | MyBiosource | 0.5mg | EUR 545 |
Interleukin-8 (IL-8) |
|||
| MBS592466-5x05mg | MyBiosource | 5x0.5mg | EUR 2205 |
Interleukin-8 (IL-8) |
|||
| MBS343081-001mg | MyBiosource | 0.01mg | EUR 275 |
Interleukin-8 (IL-8) |
|||
| MBS343081-01mg | MyBiosource | 0.1mg | EUR 710 |
Interleukin-8 (IL-8) |
|||
| MBS343081-1mg | MyBiosource | 1mg | EUR 3220 |
Interleukin-8 (IL-8) |
|||
| MBS343081-5x1mg | MyBiosource | 5x1mg | EUR 14325 |
Interleukin-8 (IL-8) |
|||
| THP-0255 | Creative BioMart | 1 vial | EUR 3198.4 |
|
Description: Protein |
|||
Interleukin 8 |
|||
| MBS596224-1mg | MyBiosource | 1mg | EUR 425 |
Interleukin 8 |
|||
| MBS596224-2mg | MyBiosource | 2mg | EUR 700 |
Interleukin 8 |
|||
| MBS596224-5mg | MyBiosource | 5mg | EUR 1505 |
Interleukin 8 Antibody |
|||
| E18-5146-1 | EnoGene | 50μg/50μl | EUR 145 |
|
Description: Available in various conjugation types. |
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Interleukin 8 Antibody |
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| E18-5146-2 | EnoGene | 100μg/100μl | EUR 225 |
|
Description: Available in various conjugation types. |
|||
Interleukin?8 Antibody |
|||
| ABF5146 | Nova Lifetech | 100ug | EUR 325 |
Interleukin 8 Antibody |
|||
| MBS8511777-005mg | MyBiosource | 0.05mg | EUR 235 |
Interleukin 8 Antibody |
|||
| MBS8511777-01mg | MyBiosource | 0.1mg | EUR 305 |
Interleukin 8 Antibody |
|||
| MBS8511777-01mLAF405M | MyBiosource | 0.1mL(AF405M) | EUR 465 |
Interleukin 8 Antibody |
|||
| MBS8511777-01mLAF546 | MyBiosource | 0.1mL(AF546) | EUR 465 |
Interleukin 8 Antibody |
|||
| MBS8511777-01mLAF750 | MyBiosource | 0.1mL(AF750) | EUR 465 |
Interleukin 8 Antibody |
|||
| MBS9601319-01mL | MyBiosource | 0.1mL | EUR 260 |
Interleukin 8 Antibody |
|||
| MBS9601319-02mL | MyBiosource | 0.2mL | EUR 305 |
Interleukin 8 Antibody |
|||
| MBS9601319-5x02mL | MyBiosource | 5x0.2mL | EUR 1220 |
Anti- Interleukin-8 receptor type B Antibody |
|||
| GWB-32D924 | GenWay Biotech | 0.05 ml | Ask for price |
Anti- Interleukin-8 receptor type B Antibody |
|||
| GWB-9B4704 | GenWay Biotech | 0.05 ml | Ask for price |
Il1f8 (untagged) - Mouse interleukin 1 family, member 8 (Il1f8), (10ug) |
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| MC210986 | Origene Technologies GmbH | 10 µg | Ask for price |
Human Interleukin-8 (IL-8) Antibody |
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| 13102-05011 | AssayPro | 150 ug | EUR 175 |
Recombinant Sheep Interleukin-8 Protein, His, E.coli-100ug |
|||
| QP6228-ec-100ug | EnQuireBio | 100ug | EUR 848.4 |
Mouse Monoclonal Anti-Human Interleukin-8 IgG |
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| AB-11110 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Mouse Anti Sheep Interleukin-8 Monoclonal Antibody |
|||
| CABT-48526MS | Creative Diagnostics | 0.25 mg | EUR 1070.4 |
Il1f8 (GFP-tagged) - Mouse interleukin 1 family member 8 (Il1f8), (10ug) |
|||
| MG220215 | Origene Technologies GmbH | 10 µg | Ask for price |
Rabbit Anti Human Interleukin-8 Polyclonal Antibody |
|||
| CPBT-65418RH | Creative Diagnostics | 0.1 mg | EUR 1057.2 |
Rabbit Anti Sheep Interleukin-8 Polyclonal Antibody |
|||
| CPBT-65420RS | Creative Diagnostics | 0.1 ml | EUR 889.2 |
Rabbit anti-dog Interleukin-8 polyclonal Antibody |
|||
| MBS1489187-005mg | MyBiosource | 0.05mg | EUR 190 |
Rabbit anti-dog Interleukin-8 polyclonal Antibody |
|||
| MBS1489187-01mg | MyBiosource | 0.1mg | EUR 270 |
Rabbit anti-dog Interleukin-8 polyclonal Antibody |
|||
| MBS1489187-5x01mg | MyBiosource | 5x0.1mg | EUR 1205 |
Interleukin 8 (IL-8) Antibody Pair |
|||
| abx378032-96tests | Abbexa | 96 tests | EUR 525 |
Human Interleukin-8 Antibody |
|||
| 33486-05111 | AssayPro | 150 ug | EUR 215 |
Sheep Interleukin-8 Antibody |
|||
| GWB-213280 | GenWay Biotech | 0.25 mg | Ask for price |
Sheep Interleukin-8 Antibody |
|||
| GWB-Q00722 | GenWay Biotech | 0.1 ml | Ask for price |
Interleukin-8 (CXCL8) Antibody |
|||
| abx402319-100g | Abbexa | 100 µg | EUR 287.5 |
Interleukin 8 (IL-8) (AP) |
|||
| MBS6121816-01mL | MyBiosource | 0.1(mL | EUR 730 |
Interleukin 8 (IL-8) (AP) |
|||
| MBS6121816-5x01mL | MyBiosource | 5x0.1mL | EUR 3135 |
Interleukin 8 (IL-8) (PE) |
|||
| MBS6122056-01mL | MyBiosource | 0.1(mL | EUR 730 |
Interleukin 8 (IL-8) (PE) |
|||
| MBS6122056-5x01mL | MyBiosource | 5x0.1mL | EUR 3135 |
Interleukin 8 (IL-8) (AP) |
|||
| MBS6482864-01mL | MyBiosource | 0.1mL | EUR 635 |
Interleukin 8 (IL-8) (AP) |
|||
| MBS6482864-5x01mL | MyBiosource | 5x0.1mL | EUR 2700 |
Interleukin 8 (IL-8) (PE) |
|||
| MBS6482874-01mL | MyBiosource | 0.1mL | EUR 635 |
Interleukin 8 (IL-8) (PE) |
|||
| MBS6482874-5x01mL | MyBiosource | 5x0.1mL | EUR 2700 |
Interleukin 8 (IL-8) (AP) |
|||
| MBS6482875-01mL | MyBiosource | 0.1mL | EUR 1100 |
Interleukin 8 (IL-8) (AP) |
|||
| MBS6482875-5x01mL | MyBiosource | 5x0.1mL | EUR 4810 |
Interleukin 8 (IL-8) (PE) |
|||
| MBS6482885-01mL | MyBiosource | 0.1mL | EUR 1100 |
Interleukin 8 (IL-8) (PE) |
|||
| MBS6482885-5x01mL | MyBiosource | 5x0.1mL | EUR 4810 |
IL-8, Interleukin-8, monkey |
|||
| RC222-19 | Bio Basic | 5ug | EUR 125.26 |
Interleukin-8 Antibody (Biotin) |
|||
| GWB-93F063 | GenWay Biotech | 0.05 mg | Ask for price |
Rabbit anti-human Interleukin-8 polyclonal Antibody |
|||
| MBS7006367-005mg | MyBiosource | 0.05mg | EUR 190 |
Rabbit anti-human Interleukin-8 polyclonal Antibody |
|||
| MBS7006367-01mg | MyBiosource | 0.1mg | EUR 270 |
Rabbit anti-human Interleukin-8 polyclonal Antibody |
|||
| MBS7006367-5x01mg | MyBiosource | 5x0.1mg | EUR 1205 |
INTERLEUKIN-8: Biotin |
|||
| MBS225885-005mg | MyBiosource | 0.05mg | EUR 645 |
INTERLEUKIN-8: Biotin |
|||
| MBS225885-5x005mg | MyBiosource | 5x0.05mg | EUR 2730 |
Interleukin 8 (IL-8) (APC) |
|||
| MBS6121864-01mL | MyBiosource | 0.1(mL | EUR 730 |
Interleukin 8 (IL-8) (APC) |
|||
| MBS6121864-5x01mL | MyBiosource | 5x0.1mL | EUR 3135 |
Interleukin 8 (IL-8) (HRP) |
|||
| MBS6122008-01mL | MyBiosource | 0.1(mL | EUR 730 |
Interleukin 8 (IL-8) (HRP) |
|||
| MBS6122008-5x01mL | MyBiosource | 5x0.1mL | EUR 3135 |
Interleukin 8 (IL-8) (APC) |
|||
| MBS6482865-01mL | MyBiosource | 0.1mL | EUR 635 |
Interleukin 8 (IL-8) (APC) |
|||
| MBS6482865-5x01mL | MyBiosource | 5x0.1mL | EUR 2700 |
Interleukin 8 (IL-8) (HRP) |
|||
| MBS6482868-01mL | MyBiosource | 0.1mL | EUR 635 |
Interleukin 8 (IL-8) (HRP) |
|||
| MBS6482868-5x01mL | MyBiosource | 5x0.1mL | EUR 2700 |
Interleukin 8 (IL-8) (APC) |
|||
| MBS6482876-01mL | MyBiosource | 0.1mL | EUR 1100 |
Interleukin 8 (IL-8) (APC) |
|||
| MBS6482876-5x01mL | MyBiosource | 5x0.1mL | EUR 4810 |
Interleukin 8 (IL-8) (HRP) |
|||
| MBS6482879-01mL | MyBiosource | 0.1mL | EUR 1100 |
Interleukin 8 (IL-8) (HRP) |
|||
| MBS6482879-5x01mL | MyBiosource | 5x0.1mL | EUR 4810 |
Interleukin 8 (IL8) Antibody |
|||
| 20-abx100960 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx100961 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx100962 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx100963 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx100964 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx100965 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx100966 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx100967 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx100969 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx100970 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx100971 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx100972 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx131832 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx131833 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx131834 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx131835 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx131836 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx131837 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx131838 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx131839 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx131840 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx137023 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| abx036426-100ug | Abbexa | 100 ug | EUR 469.2 |
Interleukin 8 (IL8) Antibody |
|||
| abx018002-100ug | Abbexa | 100 ug | EUR 410.4 |
Interleukin 8 (IL8) Antibody |
|||
| abx020956-05mg | Abbexa | 0.5 mg | EUR 1296 |
Interleukin 8 (IL8) Antibody |
|||
| 20-abx009111 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx270103 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx270152 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx270200 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx270201 | Abbexa |
|
|
Interleukin 8 (IL8) Antibody |
|||
| 20-abx173191 | Abbexa |
|
|
Lung function did not significantly differ between the three groups before treatment. After treatment, the time to relief of symptoms was significantly shorter in the GG group than that in the other two groups. forced expiratory volume in one second expiratory flow and percent predicted peak was also significantly better in the GG group compared to the other two groups.
