
Efficacy and Safety of Lebrikizumab, a High-Affinity Interleukin 13 Inhibitor, in Adults With Moderate to Severe Atopic Dermatitis: A Phase 2b Randomized Clinical Trial.
Interleukin 13 (IL-13) is a central pathogenic mediator of driving some of the features of atopic dermatitis (AD) evaluated the efficacy and safety pathophysiology.To lebrikizumab, novel, high-affinity, monoclonal antibody targeting the IL-13 which selectively prevents the formation of IL-13Rα1 / IL- 4Rα heterodimer receptor complex signals, in adults with moderate to severe AD.A phase 2b, double-blind, placebo-controlled, dose-ranging clinical trial randomized lebrikizumab injections every 4 weeks or every 2 weeks was conducted from January 23, 2018, May 23, 2019 at 57 US centers. Participants adults 18 years or older with moderate to severe AD.Patients were randomized 2: 3: 3: 3 with placebo every 2 weeks or subcutaneous injections lebrikizumab at the following doses: 125 mg every 4 weeks (250 mg loading dose [LD]), 250 mg every 4 weeks (500-mg LD), or 250 mg every 2 weeks (LD 500-mg at baseline and weeks 2) .
the primary end point was the percentage change in Eczema Area and Severity Index (EASI) (baseline to week 16 ). Secondary end points for week 16 included the proportion of patients who achieve Investigator Global Assessment score of 0 or 1 (IGA 0/1); EASI increase of at least 50%, 75%, or 90% of the baseline; the percentage change in the numerical rating scale pruritus (NRS) score goals; and NRS pruritus scored an increase of at least 4 points. safety assessment including overall treatment-emergent adverse events.A of 280 patients (mean [SD] age, 39.3 [17.5] years; 166 [59.3%] women) were randomly assigned placebo (n = 52) or lebrikizumab at a dose of 125 mg every 4 weeks (n = 73), 250 mg every 4 weeks (n = 80), or 250 mg every 2 weeks (n = 75).
Compared with placebo (EASI squares mean [SD] percentage change, -41.1% [56.5%]), lebrikizumab group showed a statistically significant increase in the dose-dependent primary endpoint at Week 16 vs. placebo: 125 mg every 4 weeks (-62.3% [37.3%], P = 0.02), 250 mg every 4 weeks (-69.2% [38.3%], P = 0.002), and 250 mg every 2 week (-72.1% [37.2%], P <0.001). Difference vs placebo-treated patients (2 of 44 [4.5%]) in pruritus NRS increase of at least 4 points seen as the beginning day two on lebrikizumab high dose group (9 of 59 [15.3%]).
Treatment-emergent adverse events were reported in 24 of 52 patients with placebo (46.2%) and in patients lebrikizumab as follows: 42 of 73 (57.5%) to 125 mg every 4 weeks, 39 of 80 (48.8% ) to 250 mg every 4 weeks, and 46 of 75 (61.3%) to 250 mg every 2 weeks; mostly mild to moderate and did not lead to discontinuation.
low rate of injection-site reactions (1 of 52 [1.9%] in the placebo group vs. 13 of 228 [5.7%] in all groups lebrikizumab), herpes virus infection (2 [3.8%] vs 8 [3 , 5%]), and conjunctivitis (0% vs 6 [2.6%]) were reported.During 16 weeks of treatment, the efficacy lebrikizumab supplied quickly, depending on the dose in a variety of clinical manifestations in adult patients with moderate to severe and demonstrated safety profile profitable. This data supports the central role of IL-13 in the pathophysiology of AD. If these findings are replicated in phase 3 studies

Signaling through interleukin -4 and interleukin – 13 cholangiocyte TMEM16A receptor complexes regulate the expression and secretion of bile.
While TMEM16A cholangiocyte activity is regulated by extracellular ATP binding membrane purinergic receptors, channels of expression is regulated by interleukin-4 (IL-4) through an unknown mechanism. The purpose of this study is therefore to identify the signaling pathways involved in the expression and secretion TMEM16A cholangiocyte.
Interleukin 2 Receptor Alpha (IL2Ra) Antibody |
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20-abx270019 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody |
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20-abx270026 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody |
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20-abx270033 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody |
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20-abx103023 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody |
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20-abx103024 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody |
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20-abx103025 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody |
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20-abx104858 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody |
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20-abx173126 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody |
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20-abx173127 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2RA) Antibody |
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20-abx213623 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2RA) Antibody |
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20-abx214719 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2RA) Antibody |
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abx140056-01mg | Abbexa | 0.1 mg | EUR 376.8 |
Interleukin 2 Receptor Alpha (IL2RA) Antibody |
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abx140058-01mg | Abbexa | 0.1 mg | EUR 360 |
Interleukin 2 Receptor Alpha (IL2RA) Antibody |
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abx149072-100ug | Abbexa | 100 ug | EUR 510 |
Interleukin 2 Receptor Alpha (IL2RA) Antibody |
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20-abx324195 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2RA) Antibody |
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abx015891-100ug | Abbexa | 100 ug | EUR 493.2 |
Interleukin 2 Receptor Alpha (IL2RA) Antibody |
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20-abx130814 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody |
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20-abx129961 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody |
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20-abx130197 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2RA) Antibody |
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20-abx323727 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2RA) Antibody |
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20-abx338834 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2RA) Antibody |
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abx430203-200ul | Abbexa | 200 ul | EUR 343.2 |
Interleukin 2 Receptor Alpha (IL2RA) Antibody |
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20-abx002170 | Abbexa |
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Mouse Monoclonal Anti-Human Interleukin-2 receptor IgG |
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AB-10410 | Alpha Diagnostics | 100 ug | EUR 416.4 |
Active Interleukin 2 Receptor Alpha (IL2Ra) |
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4-APB837Mu02 | Cloud-Clone |
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Description: Recombinant Mouse Interleukin 2 Receptor Alpha expressed in: E.coli |
Interleukin 2 Receptor Alpha (IL2Ra) Antibody (PE) |
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20-abx270765 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (PE) |
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20-abx270781 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (PE) |
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20-abx270788 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (PE) |
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20-abx270795 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE) |
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abx140057-01mg | Abbexa | 0.1 mg | EUR 410.4 |
Interleukin 2 Receptor Alpha (IL2Ra) Antibody (APC) |
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20-abx270533 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (APC) |
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20-abx270549 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (APC) |
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20-abx270556 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (APC) |
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20-abx270563 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2RA) Antibody (HRP) |
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20-abx336174 | Abbexa |
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Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody |
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abx234221-100ug | Abbexa | 100 ug | EUR 577.2 |
Interleukin 2 Receptor Alpha (IL2Ra) Antibody (FITC) |
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20-abx270301 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (FITC) |
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20-abx270317 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (FITC) |
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20-abx270324 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (FITC) |
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20-abx270331 | Abbexa |
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Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody |
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abx234254-100ug | Abbexa | 100 ug | EUR 661.2 |
Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody |
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20-abx234255 | Abbexa |
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Interleukin 13 Receptor Alpha 2 (IL13Ra2) Antibody |
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20-abx103630 | Abbexa |
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Interleukin 13 Receptor Alpha 2 (IL13Ra2) Antibody |
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20-abx103631 | Abbexa |
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Interleukin 22 Receptor Alpha 2 (IL22Ra2) Antibody |
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20-abx103632 | Abbexa |
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Interleukin 13 Receptor Alpha 2 (IL13Ra2) Antibody |
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20-abx173091 | Abbexa |
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Interleukin 22 Receptor Alpha 2 (IL22Ra2) Antibody |
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20-abx173137 | Abbexa |
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Interleukin 22 Receptor Alpha 2 (IL22Ra2) Antibody |
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20-abx173138 | Abbexa |
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Interleukin 13 Receptor Alpha 2 (IL13Ra2) Antibody |
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20-abx177103 | Abbexa |
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Interleukin 22 Receptor Alpha 2 (IL22Ra2) Antibody |
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20-abx177148 | Abbexa |
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Interleukin 22 Receptor Alpha 2 (IL22Ra2) Antibody |
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20-abx177149 | Abbexa |
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Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody |
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abx216206-100ug | Abbexa | 100 ug | EUR 526.8 |
Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody |
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20-abx210524 | Abbexa |
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Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody |
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20-abx321440 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2RA) Antibody (FITC) |
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20-abx336175 | Abbexa |
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Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody |
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20-abx113237 | Abbexa |
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Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody |
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abx030406-400ul | Abbexa | 400 ul | EUR 627.6 |
Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody |
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abx030406-80l | Abbexa | 80 µl | EUR 343.2 |
Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody |
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abx038027-100ug | Abbexa | 100 ug | EUR 469.2 |
Interleukin 22 Receptor Alpha 2 (IL22Ra2) Antibody |
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20-abx129323 | Abbexa |
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Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody |
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20-abx323397 | Abbexa |
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Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody |
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20-abx323558 | Abbexa |
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Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody |
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20-abx320223 | Abbexa |
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Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody |
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20-abx320776 | Abbexa |
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Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody |
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20-abx339164 | Abbexa |
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Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody |
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20-abx339615 | Abbexa |
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Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody |
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abx432854-200ul | Abbexa | 200 ul | EUR 460.8 |
Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody |
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20-abx006904 | Abbexa |
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Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody |
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20-abx001660 | Abbexa |
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Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody |
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20-abx007976 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (FITC) |
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20-abx274086 | Abbexa |
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Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody |
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20-abx301855 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2RA) Antibody (Biotin) |
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20-abx336176 | Abbexa |
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (Biotin) |
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20-abx273269 | Abbexa |
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Recombinant Interleukin 2 Receptor Alpha (IL2Ra) |
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4-RPB837Bo01 | Cloud-Clone |
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Description: Recombinant Bovine Interleukin 2 Receptor Alpha expressed in: E.coli |
Recombinant Interleukin 2 Receptor Alpha (IL2Ra) |
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4-RPB837Hu01 | Cloud-Clone |
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Description: Recombinant Human Interleukin 2 Receptor Alpha expressed in: E.coli |
Recombinant Interleukin 2 Receptor Alpha (IL2Ra) |
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4-RPB837Mu01 | Cloud-Clone |
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Description: Recombinant Mouse Interleukin 2 Receptor Alpha expressed in: E.coli |
Recombinant Interleukin 2 Receptor Alpha (IL2Ra) |
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4-RPB837Po01 | Cloud-Clone |
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Description: Recombinant Pig Interleukin 2 Receptor Alpha expressed in: E.coli |
Recombinant Interleukin 2 Receptor Alpha (IL2Ra) |
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4-RPB837Ra01 | Cloud-Clone |
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Description: Recombinant Rat Interleukin 2 Receptor Alpha expressed in: E.coli |
Recombinant Interleukin 2 Receptor Alpha (IL2Ra) |
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4-RPB837Ra02 | Cloud-Clone |
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Description: Recombinant Rat Interleukin 2 Receptor Alpha expressed in: E.coli |
Rat Interleukin 2 Receptor Alpha (IL2Ra) Protein |
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20-abx067495 | Abbexa |
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Pig Interleukin 2 Receptor Alpha (IL2Ra) Protein |
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20-abx168471 | Abbexa |
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Rat Interleukin 2 Receptor Alpha (IL2Ra) Protein |
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20-abx168561 | Abbexa |
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Cow Interleukin 2 Receptor Alpha (IL2Ra) Protein |
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20-abx166310 | Abbexa |
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Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody (HRP) |
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20-abx316446 | Abbexa |
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Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody (FITC) |
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20-abx316447 | Abbexa |
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Mouse Interleukin 2 Receptor Alpha (IL2Ra) Protein |
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20-abx067496 | Abbexa |
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Human Interleukin 2 Receptor Alpha (IL2Ra) Protein |
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20-abx067497 | Abbexa |
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Interleukin 2 Receptor Subunit Alpha (IL2RA) Antibody |
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20-abx159563 | Abbexa |
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Interleukin 3 Receptor Alpha (IL3RA) Antibody |
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20-abx134363 | Abbexa |
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Interleukin 3 Receptor Alpha (IL3RA) Antibody |
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abx234277-100ug | Abbexa | 100 ug | EUR 661.2 |
Interleukin 5 Receptor Alpha (IL5RA) Antibody |
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abx234280-100ug | Abbexa | 100 ug | EUR 577.2 |
Interleukin 3 Receptor Alpha (IL3Ra) Antibody |
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20-abx103027 | Abbexa |
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Interleukin 3 Receptor Alpha (IL3Ra) Antibody |
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20-abx103028 | Abbexa |
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Interleukin 3 Receptor Alpha (IL3Ra) Antibody |
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20-abx103029 | Abbexa |
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Interleukin 5 Receptor Alpha (IL5Ra) Antibody |
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20-abx103030 | Abbexa |
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Interleukin 3 Receptor Alpha (IL3Ra) Antibody |
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20-abx173154 | Abbexa |
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Interleukin 5 Receptor Alpha (IL5Ra) Antibody |
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20-abx173178 | Abbexa |
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Interleukin 8 Receptor Alpha (IL8Ra) Antibody |
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20-abx173192 | Abbexa |
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Interleukin 8 Receptor Alpha (IL8Ra) Antibody |
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20-abx173193 | Abbexa |
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Interleukin 8 Receptor Alpha (IL8Ra) Antibody |
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20-abx173194 | Abbexa |
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Interleukin 5 Receptor Alpha (IL5Ra) Antibody |
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20-abx177187 | Abbexa |
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Interleukin 8 Receptor Alpha (IL8Ra) Antibody |
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20-abx177202 | Abbexa |
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Interleukin 8 Receptor Alpha (IL8Ra) Antibody |
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20-abx177203 | Abbexa |
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Interleukin 8 Receptor Alpha (IL8Ra) Antibody |
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20-abx177204 | Abbexa |
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Interleukin 8 Receptor Alpha (IL8Ra) Antibody |
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20-abx177205 | Abbexa |
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Interleukin 3 Receptor Alpha (IL3RA) Antibody |
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20-abx213242 | Abbexa |
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Interleukin 3 Receptor Alpha (IL3RA) Antibody |
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20-abx210658 | Abbexa |
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Interleukin 5 Receptor Alpha (IL5RA) Antibody |
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20-abx211942 | Abbexa |
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Interleukin 5 Receptor Alpha (IL5RA) Antibody |
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20-abx211943 | Abbexa |
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Interleukin 3 Receptor Alpha (IL3RA) Antibody |
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abx139575-01mg | Abbexa | 0.1 mg | EUR 427.2 |
Interleukin 5 Receptor Alpha (IL5RA) Antibody |
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20-abx325299 | Abbexa |
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Interleukin 3 Receptor Alpha (IL3RA) Antibody |
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20-abx113253 | Abbexa |
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Interleukin 5 Receptor Alpha (IL5RA) Antibody |
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20-abx113255 | Abbexa |
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Interleukin 5 Receptor Alpha (IL5RA) Antibody |
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abx030870-400ul | Abbexa | 400 ul | EUR 627.6 |
Interleukin 5 Receptor Alpha (IL5RA) Antibody |
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abx030870-80l | Abbexa | 80 µl | EUR 343.2 |
Interleukin 5 Receptor Alpha (IL5RA) Antibody |
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abx032450-400ul | Abbexa | 400 ul | EUR 627.6 |
Interleukin 5 Receptor Alpha (IL5RA) Antibody |
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abx032450-80l | Abbexa | 80 µl | EUR 343.2 |
Interleukin 3 Receptor Alpha (IL3RA) Antibody |
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abx015893-100ul | Abbexa | 100 ul | EUR 493.2 |
Interleukin 3 Receptor Alpha (IL3RA) Antibody |
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abx015894-100ug | Abbexa | 100 ug | EUR 493.2 |
Interleukin 3 Receptor Alpha (IL3RA) Antibody |
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abx034887-400ul | Abbexa | 400 ul | EUR 627.6 |
Interleukin 3 Receptor Alpha (IL3RA) Antibody |
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abx034887-80l | Abbexa | 80 µl | EUR 343.2 |
Interleukin 5 Receptor Alpha (IL5RA) Antibody |
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20-abx124275 | Abbexa |
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Interleukin 5 Receptor Alpha (IL5Ra) Antibody |
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20-abx129750 | Abbexa |
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Interleukin 3 Receptor Alpha (IL3RA) Antibody |
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20-abx323399 | Abbexa |
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Interleukin 5 Receptor Alpha (IL5RA) Antibody |
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20-abx323826 | Abbexa |
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Interleukin 3 Receptor Alpha (IL3RA) Antibody |
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abx430549-200ul | Abbexa | 200 ul | EUR 460.8 |
Interleukin 3 Receptor Alpha (IL3RA) Antibody |
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20-abx002867 | Abbexa |
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Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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20-abx134375 | Abbexa |
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Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx200195-100ug | Abbexa | 100 ug | EUR 393.6 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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20-abx200751 | Abbexa |
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Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx139566-01mg | Abbexa | 0.1 mg | EUR 427.2 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx139567-01mg | Abbexa | 0.1 mg | EUR 427.2 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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20-abx121575 | Abbexa |
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Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx412774-01mg | Abbexa | 0.1 mg | EUR 543.6 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx025269-100ul | Abbexa | 100 ul | EUR 627.6 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx413741-02mg | Abbexa | 0.2 mg | EUR 678 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx413847-01mg | Abbexa | 0.1 mg | EUR 543.6 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx415231-01mg | Abbexa | 0.1 mg | EUR 543.6 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx415240-01mg | Abbexa | 0.1 mg | EUR 543.6 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx414178-01mg | Abbexa | 0.1 mg | EUR 543.6 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx414536-05mg | Abbexa | 0.5 mg | EUR 994.8 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx414537-01mg | Abbexa | 0.1 mg | EUR 526.8 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx414539-025mg | Abbexa | 0.25 mg | EUR 678 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx414966-1mg | Abbexa | 1 mg | EUR 994.8 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
|||
abx414967-01mg | Abbexa | 0.1 mg | EUR 526.8 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx414968-1mg | Abbexa | 1 mg | EUR 994.8 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
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abx412877-025mg | Abbexa | 0.25 mg | EUR 678 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
|||
abx412878-01mg | Abbexa | 0.1 mg | EUR 526.8 |
Interleukin-2 Receptor Subunit Alpha (CD25) Antibody |
|||
abx413298-01mg | Abbexa | 0.1 mg | EUR 610.8 |
Cow Interleukin 2 Receptor Alpha (IL2Ra) CLIA Kit |
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20-abx493142 | Abbexa |
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Rat Interleukin 2 Receptor Alpha (IL2Ra) CLIA Kit |
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20-abx493145 | Abbexa |
|
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Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody (Biotin) |
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20-abx316448 | Abbexa |
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Interleukin 13 Receptor Alpha 2 (IL13Ra2) Antibody (Biotin) |
|||
20-abx272541 | Abbexa |
|
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Interleukin 10 Receptor Alpha (IL10RA) Antibody |
|||
abx234213-100ug | Abbexa | 100 ug | EUR 661.2 |
Interleukin 11 Receptor Alpha (IL11RA) Antibody |
|||
abx234217-100ug | Abbexa | 100 ug | EUR 577.2 |
Interleukin 10 Receptor Alpha (IL10Ra) Antibody |
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20-abx103276 | Abbexa |
|
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Interleukin 10 Receptor Alpha (IL10Ra) Antibody |
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20-abx103277 | Abbexa |
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The study was conducted in normal mice cholangiocyte polarized monolayers, Mz-Cha-1 human bladder cells, and cholangiocytes isolated from murine liver tissue. The results showed that all models of bile reveal a complex receptor IL-4RA / IL-13Ra1.