Interleukin 13

Interleukin 13

IL-13) is a protein that in humans is encoded by the IL13 gene
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Efficacy and Safety of Lebrikizumab, a High-Affinity Interleukin 13 Inhibitor, in Adults With Moderate to Severe Atopic Dermatitis: A Phase 2b Randomized Clinical Trial.

Interleukin 13 (IL-13) is a central pathogenic mediator of driving some of the features of atopic dermatitis (AD) evaluated the efficacy and safety pathophysiology.To lebrikizumab, novel, high-affinity, monoclonal antibody targeting the IL-13 which selectively prevents the formation of IL-13Rα1 / IL- 4Rα heterodimer receptor complex signals, in adults with moderate to severe AD.A phase 2b, double-blind, placebo-controlled, dose-ranging clinical trial randomized lebrikizumab injections every 4 weeks or every 2 weeks was conducted from January 23, 2018, May 23, 2019 at 57 US centers. Participants adults 18 years or older with moderate to severe AD.Patients were randomized 2: 3: 3: 3 with placebo every 2 weeks or subcutaneous injections lebrikizumab at the following doses: 125 mg every 4 weeks (250 mg loading dose [LD]), 250 mg every 4 weeks (500-mg LD), or 250 mg every 2 weeks (LD 500-mg at baseline and weeks 2) .

the primary end point was the percentage change in Eczema Area and Severity Index (EASI) (baseline to week 16 ). Secondary end points for week 16 included the proportion of patients who achieve Investigator Global Assessment score of 0 or 1 (IGA 0/1); EASI increase of at least 50%, 75%, or 90% of the baseline; the percentage change in the numerical rating scale pruritus (NRS) score goals; and NRS pruritus scored an increase of at least 4 points. safety assessment including overall treatment-emergent adverse events.A of 280 patients (mean [SD] age, 39.3 [17.5] years; 166 [59.3%] women) were randomly assigned placebo (n = 52) or lebrikizumab at a dose of 125 mg every 4 weeks (n = 73), 250 mg every 4 weeks (n = 80), or 250 mg every 2 weeks (n = 75).

Compared with placebo (EASI squares mean [SD] percentage change, -41.1% [56.5%]), lebrikizumab group showed a statistically significant increase in the dose-dependent primary endpoint at Week 16 vs. placebo: 125 mg every 4 weeks (-62.3% [37.3%], P = 0.02), 250 mg every 4 weeks (-69.2% [38.3%], P = 0.002), and 250 mg every 2 week (-72.1% [37.2%], P <0.001). Difference vs placebo-treated patients (2 of 44 [4.5%]) in pruritus NRS increase of at least 4 points seen as the beginning day two on lebrikizumab high dose group (9 of 59 [15.3%]).

Treatment-emergent adverse events were reported in 24 of 52 patients with placebo (46.2%) and in patients lebrikizumab as follows: 42 of 73 (57.5%) to 125 mg every 4 weeks, 39 of 80 (48.8% ) to 250 mg every 4 weeks, and 46 of 75 (61.3%) to 250 mg every 2 weeks; mostly mild to moderate and did not lead to discontinuation.

low rate of injection-site reactions (1 of 52 [1.9%] in the placebo group vs. 13 of 228 [5.7%] in all groups lebrikizumab), herpes virus infection (2 [3.8%] vs 8 [3 , 5%]), and conjunctivitis (0% vs 6 [2.6%]) were reported.During 16 weeks of treatment, the efficacy lebrikizumab supplied quickly, depending on the dose in a variety of clinical manifestations in adult patients with moderate to severe and demonstrated safety profile profitable. This data supports the central role of IL-13 in the pathophysiology of AD. If these findings are replicated in phase 3 studies

Efficacy and Safety of Lebrikizumab, a High-Affinity <em>Interleukin</em> <em>13</em> Inhibitor, in Adults With Moderate to Severe Atopic Dermatitis: A Phase 2b Randomized Clinical Trial.
Efficacy and Safety of Lebrikizumab, a High-Affinity Interleukin 13 Inhibitor, in Adults With Moderate to Severe Atopic Dermatitis: A Phase 2b Randomized Clinical Trial.

Signaling through interleukin -4 and interleukin – 13 cholangiocyte TMEM16A receptor complexes regulate the expression and secretion of bile.

While TMEM16A cholangiocyte activity is regulated by extracellular ATP binding membrane purinergic receptors, channels of expression is regulated by interleukin-4 (IL-4) through an unknown mechanism. The purpose of this study is therefore to identify the signaling pathways involved in the expression and secretion TMEM16A cholangiocyte.

Interleukin 2 Receptor Alpha (IL2Ra) Antibody

20-abx103023
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody

20-abx103024
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody

20-abx103025
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody

20-abx104858
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody

20-abx129961
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody

20-abx130197
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Interleukin 2 Receptor Alpha (IL2RA) Antibody

20-abx130814
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  • 100 ug
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Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx149072-100ug 100 ug
EUR 510

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx140056-01mg 0.1 mg
EUR 376.8

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx140058-01mg 0.1 mg
EUR 360

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx015891-100ug 100 ug
EUR 493.2

Interleukin 2 Receptor Alpha (IL2RA) Antibody

20-abx002170
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody

20-abx270003
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody

20-abx270019
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody

20-abx270026
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody

20-abx270033
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Interleukin 2 Receptor Alpha (IL2RA) Antibody

20-abx213623
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  • 100 ul
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Interleukin 2 Receptor Alpha (IL2RA) Antibody

20-abx214719
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  • 100 ul
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody

20-abx173126
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  • 1 mg
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody

20-abx173127
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Interleukin 2 Receptor Alpha (IL2RA) Antibody

20-abx338834
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Interleukin 2 Receptor Alpha (IL2RA) Antibody

20-abx324195
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Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx430203-200ul 200 ul
EUR 343.2

Interleukin 2 Receptor Alpha (IL2RA) Antibody

20-abx323727
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Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx002170-100l 100 µl
EUR 400

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx002170-20l 20 µl
EUR 175

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx002170-50l 50 µl
EUR 275

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx104858-100g 100 µg
EUR 850

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx104858-20g 20 µg
EUR 287.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx104858-50g 50 µg
EUR 375

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx103023-100l 100 µl
EUR 262.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx103023-1ml 1 ml
EUR 712.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx103023-200l 200 µl
EUR 325

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx103024-100l 100 µl
EUR 275

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx103024-1ml 1 ml
EUR 775

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx103024-200l 200 µl
EUR 350

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx103025-100l 100 µl
EUR 275

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx103025-1ml 1 ml
EUR 775

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx103025-200l 200 µl
EUR 350

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx159563-100g 100 µg Ask for price

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx159563-10g 10 µg
EUR 187.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx159563-50g 50 µg
EUR 250

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx129961-100l 100 µl
EUR 287.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx129961-1ml 1 ml
EUR 850

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx129961-200l 200 µl
EUR 375

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx130197-100l 100 µl
EUR 275

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx130197-1ml 1 ml
EUR 775

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx130197-200l 200 µl
EUR 350

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx173126-100l 100 µl
EUR 275

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx173126-1ml 1 ml
EUR 750

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx173126-200l 200 µl
EUR 337.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx173127-100l 100 µl
EUR 900

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx173127-1ml 1 ml Ask for price

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx173127-200l 200 µl Ask for price

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx213623-100l 100 µl
EUR 250

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx025269-400l 400 µl Ask for price

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx025269-80l 80 µl
EUR 518.75

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx015891-1mg 1 mg
EUR 362.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx270003-1ml 1 ml
EUR 387.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx270003-200l 200 µl
EUR 275

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx270019-1ml 1 ml
EUR 387.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx270019-200l 200 µl
EUR 275

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx270026-1ml 1 ml
EUR 387.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx270026-200l 200 µl
EUR 275

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx270033-1ml 1 ml
EUR 387.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx270033-200l 200 µl
EUR 275

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx130814-100l 100 µl
EUR 262.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx130814-500l 500 µl
EUR 337.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx149072-1096tests 10 × 96 tests Ask for price

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx149072-596tests 5 × 96 tests
EUR 387.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx149072-96tests 96 tests
EUR 300

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx139566-100l 100 µl
EUR 275

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx139566-500l 500 µl
EUR 1837.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx139567-100l 100 µl
EUR 275

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx139567-500l 500 µl Ask for price

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx214719-100g 100 µg
EUR 350

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx214719-25g 25 µg
EUR 250

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx228886-100g 100 µg
EUR 100

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx228887-100g 100 µg
EUR 50

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx239909-100l 100 µl Ask for price

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx239909-50l 50 µl
EUR 350

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx338834-100l 100 µl
EUR 250

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx338834-50l 50 µl
EUR 162.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx323727-100g 100 µg
EUR 250

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx323727-50g 50 µg
EUR 187.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx324195-100g 100 µg
EUR 250

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx324195-50g 50 µg
EUR 187.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx375003-96tests 96 tests
EUR 225

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx412774-200l 200 µl
EUR 362.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx412877-200l 200 µl
EUR 462.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx412878-200l 200 µl
EUR 337.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx413298-200l 200 µl
EUR 425

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx413741-200l 200 µl
EUR 462.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx413847-200l 200 µl
EUR 362.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx414178-200l 200 µl
EUR 362.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx414537-200l 200 µl
EUR 350

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx414539-200l 200 µl
EUR 487.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx415231-200l 200 µl
EUR 362.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx415240-200l 200 µl
EUR 362.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody

abx430203-200l 200 µl
EUR 250

Rabbit Anti-Human Interleukin 6 receptor (IL-6RCD126, gp80/IL-6RA)

AB-22124 50 ul
EUR 562.8

Interleukin-2 receptor subunit alpha

AP84148 1mg
EUR 2640

Interleukin-2 receptor subunit alpha

AP84395 1mg
EUR 2640

Interleukin-2 receptor subunit alpha

AP84505 1mg
EUR 2640

Interleukin-2 receptor subunit alpha

AP84541 1mg
EUR 2640

Interleukin-2 receptor subunit alpha

AP84626 1mg
EUR 2640

Interleukin-2 receptor subunit alpha

AP85055 1mg
EUR 2640

Rabbit Anti-Human Interleukin-1 receptor-like 1 (IL1RL1) IgG (aff pure)

AB-23064-A 100ug
EUR 578.4

Rabbit Anti-Human Interleukin-1 receptor-like 1 (IL1RL1) IgG (aff pure)

AB-23065-A 100ug
EUR 578.4

Rabbit Anti-Human Interleukin-1 receptor-like 1 (IL1RL1) IgG (aff pure)

AB-23066-A 100ug
EUR 578.4

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx140057-01mg 0.1 mg
EUR 410.4

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (PE)

20-abx270765
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (PE)

20-abx270781
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (PE)

20-abx270788
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (PE)

20-abx270795
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Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx270765-1ml 1 ml
EUR 625

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx270765-200l 200 µl
EUR 525

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx270781-1ml 1 ml
EUR 1025

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx270781-200l 200 µl
EUR 625

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx270788-1ml 1 ml
EUR 1025

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx270788-200l 200 µl
EUR 625

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx270795-1ml 1 ml
EUR 625

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx270795-200l 200 µl
EUR 525

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx139568-100l 100 µl
EUR 400

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx139568-500l 500 µl Ask for price

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx228890-100g 100 µg
EUR 125

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx229426-100g 100 µg
EUR 62.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx412879-200l 200 µl
EUR 862.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx413745-200l 200 µl
EUR 487.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx414179-200l 200 µl
EUR 637.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx414538-200l 200 µl
EUR 512.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)

abx415232-200l 200 µl
EUR 637.5

Active Interleukin 2 Receptor Alpha (IL2Ra)

APB837Hu61 10ug
EUR 204

Active Interleukin 2 Receptor Alpha (IL2Ra)

APB837Mu02 10ug
EUR 192

Active Interleukin 2 Receptor Alpha (IL2Ra)

4-APB837Mu02
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  • 5 mg
Description: Recombinant Mouse Interleukin 2 Receptor Alpha expressed in: E.coli

Active Interleukin 2 Receptor Alpha (IL2Ra)

RPU54941-100ug 100ug
EUR 591.8

Active Interleukin 2 Receptor Alpha (IL2Ra)

RPU54941-1mg 1mg
EUR 2620.8

Active Interleukin 2 Receptor Alpha (IL2Ra)

RPU54941-50ug 50ug
EUR 475.2

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (APC)

20-abx270533
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  • 100 tests
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (APC)

20-abx270549
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  • 100 tests
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (APC)

20-abx270556
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  • 100 tests
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Interleukin 2 Receptor Alpha (IL2Ra) Antibody (APC)

20-abx270563
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  • 100 tests
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Interleukin 2 Receptor Alpha (IL2RA) Antibody (HRP)

20-abx336174
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
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Interleukin 2 Receptor Alpha (IL2RA) Antibody (APC)

abx270533-1ml 1 ml
EUR 737.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody (APC)

abx270533-200l 200 µl
EUR 612.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody (APC)

abx270549-1ml 1 ml
EUR 1200

Interleukin 2 Receptor Alpha (IL2RA) Antibody (APC)

abx270549-200l 200 µl
EUR 737.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody (APC)

abx270556-1ml 1 ml
EUR 1200

Interleukin 2 Receptor Alpha (IL2RA) Antibody (APC)

abx270556-200l 200 µl
EUR 737.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody (APC)

abx270563-1ml 1 ml
EUR 737.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody (APC)

abx270563-200l 200 µl
EUR 612.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody (APC)

abx139571-100l 100 µl
EUR 400

Interleukin 2 Receptor Alpha (IL2RA) Antibody (APC)

abx139571-500l 500 µl Ask for price

Interleukin 2 Receptor Alpha (IL2RA) Antibody (APC)

abx228891-100g 100 µg
EUR 125

Interleukin 2 Receptor Alpha (IL2RA) Antibody (APC)

abx229427-100g 100 µg
EUR 62.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody (HRP)

abx336174-100g 100 µg
EUR 362.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody (HRP)

abx336174-20g 20 µg
EUR 162.5

Interleukin 2 Receptor Alpha (IL2RA) Antibody (HRP)

abx336174-50g 50 µg
EUR 250

The study was conducted in normal mice cholangiocyte polarized monolayers, Mz-Cha-1 human bladder cells, and cholangiocytes isolated from murine liver tissue. The results showed that all models of bile reveal a complex receptor IL-4RA / IL-13Ra1.