Efficacy and Safety of Lebrikizumab, a High-Affinity Interleukin 13 Inhibitor, in Adults With Moderate to Severe Atopic Dermatitis: A Phase 2b Randomized Clinical Trial.

Interleukin 13 (IL-13) is a central pathogenic mediator of driving some of the features of atopic dermatitis (AD) evaluated the efficacy and safety pathophysiology.To lebrikizumab, novel, high-affinity, monoclonal antibody targeting the IL-13 which selectively prevents the formation of IL-13Rα1 / IL- 4Rα heterodimer receptor complex signals, in adults with moderate to severe AD.A phase 2b, double-blind, placebo-controlled, dose-ranging clinical trial randomized lebrikizumab injections every 4 weeks or every 2 weeks was conducted from January 23, 2018, May 23, 2019 at 57 US centers. Participants adults 18 years or older with moderate to severe AD.Patients were randomized 2: 3: 3: 3 with placebo every 2 weeks or subcutaneous injections lebrikizumab at the following doses: 125 mg every 4 weeks (250 mg loading dose [LD]), 250 mg every 4 weeks (500-mg LD), or 250 mg every 2 weeks (LD 500-mg at baseline and weeks 2) .

the primary end point was the percentage change in Eczema Area and Severity Index (EASI) (baseline to week 16 ). Secondary end points for week 16 included the proportion of patients who achieve Investigator Global Assessment score of 0 or 1 (IGA 0/1); EASI increase of at least 50%, 75%, or 90% of the baseline; the percentage change in the numerical rating scale pruritus (NRS) score goals; and NRS pruritus scored an increase of at least 4 points. safety assessment including overall treatment-emergent adverse events.A of 280 patients (mean [SD] age, 39.3 [17.5] years; 166 [59.3%] women) were randomly assigned placebo (n = 52) or lebrikizumab at a dose of 125 mg every 4 weeks (n = 73), 250 mg every 4 weeks (n = 80), or 250 mg every 2 weeks (n = 75).

Compared with placebo (EASI squares mean [SD] percentage change, -41.1% [56.5%]), lebrikizumab group showed a statistically significant increase in the dose-dependent primary endpoint at Week 16 vs. placebo: 125 mg every 4 weeks (-62.3% [37.3%], P = 0.02), 250 mg every 4 weeks (-69.2% [38.3%], P = 0.002), and 250 mg every 2 week (-72.1% [37.2%], P <0.001). Difference vs placebo-treated patients (2 of 44 [4.5%]) in pruritus NRS increase of at least 4 points seen as the beginning day two on lebrikizumab high dose group (9 of 59 [15.3%]).

Treatment-emergent adverse events were reported in 24 of 52 patients with placebo (46.2%) and in patients lebrikizumab as follows: 42 of 73 (57.5%) to 125 mg every 4 weeks, 39 of 80 (48.8% ) to 250 mg every 4 weeks, and 46 of 75 (61.3%) to 250 mg every 2 weeks; mostly mild to moderate and did not lead to discontinuation.

low rate of injection-site reactions (1 of 52 [1.9%] in the placebo group vs. 13 of 228 [5.7%] in all groups lebrikizumab), herpes virus infection (2 [3.8%] vs 8 [3 , 5%]), and conjunctivitis (0% vs 6 [2.6%]) were reported.During 16 weeks of treatment, the efficacy lebrikizumab supplied quickly, depending on the dose in a variety of clinical manifestations in adult patients with moderate to severe and demonstrated safety profile profitable. This data supports the central role of IL-13 in the pathophysiology of AD. If these findings are replicated in phase 3 studies

Signaling through interleukin -4 and interleukin – 13 cholangiocyte TMEM16A receptor complexes regulate the expression and secretion of bile.

While TMEM16A cholangiocyte activity is regulated by extracellular ATP binding membrane purinergic receptors, channels of expression is regulated by interleukin-4 (IL-4) through an unknown mechanism. The purpose of this study is therefore to identify the signaling pathways involved in the expression and secretion TMEM16A cholangiocyte.

Interleukin 2 Receptor Alpha (IL2Ra) Antibody
20-abx270019	Abbexa	EUR 560.40 EUR 644.40 EUR 326.40 EUR 978.00 EUR 427.20	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 2 Receptor Alpha (IL2Ra) Antibody
20-abx270026	Abbexa	EUR 560.40 EUR 644.40 EUR 326.40 EUR 978.00 EUR 427.20	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 2 Receptor Alpha (IL2Ra) Antibody
20-abx270033	Abbexa	EUR 560.40 EUR 644.40 EUR 326.40 EUR 978.00 EUR 427.20	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 2 Receptor Alpha (IL2Ra) Antibody
20-abx103023	Abbexa	EUR 493.20 EUR 159.60 EUR 1378.80 EUR 678.00 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 2 Receptor Alpha (IL2Ra) Antibody
20-abx103024	Abbexa	EUR 526.80 EUR 159.60 EUR 1479.60 EUR 710.40 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 2 Receptor Alpha (IL2Ra) Antibody
20-abx103025	Abbexa	EUR 526.80 EUR 159.60 EUR 1496.40 EUR 710.40 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 2 Receptor Alpha (IL2Ra) Antibody
20-abx104858	Abbexa	EUR 560.40 EUR 159.60 EUR 1629.60 EUR 777.60 EUR 427.20	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 2 Receptor Alpha (IL2Ra) Antibody
20-abx173126	Abbexa	EUR 978.00 EUR 510.00	1 mg 200 ug

Interleukin 2 Receptor Alpha (IL2Ra) Antibody
20-abx173127	Abbexa	EUR 1128.00 EUR 577.20	1 mg 200 ug

Interleukin 2 Receptor Alpha (IL2RA) Antibody
20-abx213623	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Interleukin 2 Receptor Alpha (IL2RA) Antibody
20-abx214719	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Interleukin 2 Receptor Alpha (IL2RA) Antibody
abx140056-01mg	Abbexa	0.1 mg	EUR 376.8

Interleukin 2 Receptor Alpha (IL2RA) Antibody
abx140058-01mg	Abbexa	0.1 mg	EUR 360

Interleukin 2 Receptor Alpha (IL2RA) Antibody
abx149072-100ug	Abbexa	100 ug	EUR 510

Interleukin 2 Receptor Alpha (IL2RA) Antibody
20-abx324195	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Interleukin 2 Receptor Alpha (IL2RA) Antibody
abx015891-100ug	Abbexa	100 ug	EUR 493.2

Interleukin 2 Receptor Alpha (IL2RA) Antibody
20-abx130814	Abbexa	EUR 510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 2 Receptor Alpha (IL2Ra) Antibody
20-abx129961	Abbexa	EUR 560.40 EUR 159.60 EUR 1612.80 EUR 760.80 EUR 427.20	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 2 Receptor Alpha (IL2Ra) Antibody
20-abx130197	Abbexa	EUR 526.80 EUR 159.60 EUR 1496.40 EUR 710.40 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 2 Receptor Alpha (IL2RA) Antibody
20-abx323727	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Interleukin 2 Receptor Alpha (IL2RA) Antibody
20-abx338834	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 2 Receptor Alpha (IL2RA) Antibody
abx430203-200ul	Abbexa	200 ul	EUR 343.2

Interleukin 2 Receptor Alpha (IL2RA) Antibody
20-abx002170	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Mouse Monoclonal Anti-Human Interleukin-2 receptor IgG
AB-10410	Alpha Diagnostics	100 ug	EUR 416.4

Active Interleukin 2 Receptor Alpha (IL2Ra)
4-APB837Mu02	Cloud-Clone	EUR 636.10 EUR 294.00 EUR 2055.36 EUR 765.12 EUR 1410.24 EUR 501.60 EUR 4958.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Interleukin 2 Receptor Alpha expressed in: E.coli

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (PE)
20-abx270765	Abbexa	EUR 727.20 EUR 861.60 EUR 393.60 EUR 1362.00 EUR 526.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (PE)
20-abx270781	Abbexa	EUR 727.20 EUR 861.60 EUR 393.60 EUR 1362.00 EUR 526.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (PE)
20-abx270788	Abbexa	EUR 727.20 EUR 861.60 EUR 393.60 EUR 1362.00 EUR 526.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (PE)
20-abx270795	Abbexa	EUR 727.20 EUR 861.60 EUR 393.60 EUR 1362.00 EUR 526.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 2 Receptor Alpha (IL2RA) Antibody (PE)
abx140057-01mg	Abbexa	0.1 mg	EUR 410.4

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (APC)
20-abx270533	Abbexa	EUR 844.80 EUR 994.80 EUR 444.00 EUR 1596.00 EUR 594.00	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (APC)
20-abx270549	Abbexa	EUR 844.80 EUR 994.80 EUR 444.00 EUR 1596.00 EUR 594.00	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (APC)
20-abx270556	Abbexa	EUR 844.80 EUR 994.80 EUR 444.00 EUR 1596.00 EUR 594.00	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (APC)
20-abx270563	Abbexa	EUR 844.80 EUR 994.80 EUR 444.00 EUR 1596.00 EUR 594.00	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 2 Receptor Alpha (IL2RA) Antibody (HRP)
20-abx336174	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody
abx234221-100ug	Abbexa	100 ug	EUR 577.2

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (FITC)
20-abx270301	Abbexa	EUR 627.60 EUR 727.20 EUR 360.00 EUR 1128.00 EUR 460.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (FITC)
20-abx270317	Abbexa	EUR 627.60 EUR 727.20 EUR 360.00 EUR 1128.00 EUR 460.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (FITC)
20-abx270324	Abbexa	EUR 627.60 EUR 727.20 EUR 360.00 EUR 1128.00 EUR 460.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (FITC)
20-abx270331	Abbexa	EUR 627.60 EUR 727.20 EUR 360.00 EUR 1128.00 EUR 460.80	100 tests 200 tests 25 tests 500 tests 50 tests

Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody
abx234254-100ug	Abbexa	100 ug	EUR 661.2

Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody
20-abx234255	Abbexa	EUR 661.20 EUR 3166.80	100 ug 1 mg

Interleukin 13 Receptor Alpha 2 (IL13Ra2) Antibody
20-abx103630	Abbexa	EUR 493.20 EUR 159.60 EUR 1378.80 EUR 678.00 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 13 Receptor Alpha 2 (IL13Ra2) Antibody
20-abx103631	Abbexa	EUR 510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 22 Receptor Alpha 2 (IL22Ra2) Antibody
20-abx103632	Abbexa	EUR 543.60 EUR 159.60 EUR 1562.40 EUR 744.00 EUR 410.40	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 13 Receptor Alpha 2 (IL13Ra2) Antibody
20-abx173091	Abbexa	EUR 978.00 EUR 510.00	1 mg 200 ug

Interleukin 22 Receptor Alpha 2 (IL22Ra2) Antibody
20-abx173137	Abbexa	EUR 1028.40 EUR 526.80	1 mg 200 ug

Interleukin 22 Receptor Alpha 2 (IL22Ra2) Antibody
20-abx173138	Abbexa	EUR 1095.60 EUR 560.40	1 mg 200 ug

Interleukin 13 Receptor Alpha 2 (IL13Ra2) Antibody
20-abx177103	Abbexa	EUR 1412.40 EUR 693.60	1 mg 200 ug

Interleukin 22 Receptor Alpha 2 (IL22Ra2) Antibody
20-abx177148	Abbexa	EUR 1446.00 EUR 693.60	1 mg 200 ug

Interleukin 22 Receptor Alpha 2 (IL22Ra2) Antibody
20-abx177149	Abbexa	EUR 1479.60 EUR 710.40	1 mg 200 ug

Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody
abx216206-100ug	Abbexa	100 ug	EUR 526.8

Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody
20-abx210524	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody
20-abx321440	Abbexa	EUR 360.00 EUR 292.80	100 ul 50 ul

Interleukin 2 Receptor Alpha (IL2RA) Antibody (FITC)
20-abx336175	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody
20-abx113237	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody
abx030406-400ul	Abbexa	400 ul	EUR 627.6

Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody
abx030406-80l	Abbexa	80 µl	EUR 343.2

Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody
abx038027-100ug	Abbexa	100 ug	EUR 469.2

Interleukin 22 Receptor Alpha 2 (IL22Ra2) Antibody
20-abx129323	Abbexa	EUR 526.80 EUR 159.60 EUR 1479.60 EUR 710.40 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody
20-abx323397	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody
20-abx323558	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody
20-abx320223	Abbexa	EUR 360.00 EUR 292.80	100 ul 50 ul

Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody
20-abx320776	Abbexa	EUR 526.80 EUR 393.60	100 ul 50 ul

Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody
20-abx339164	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody
20-abx339615	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody
abx432854-200ul	Abbexa	200 ul	EUR 460.8

Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody
20-abx006904	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Interleukin 13 Receptor Alpha 2 (IL13RA2) Antibody
20-abx001660	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody
20-abx007976	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (FITC)
20-abx274086	Abbexa	EUR 594.00 EUR 309.60 EUR 1746.00 EUR 828.00 EUR 477.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody
20-abx301855	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 2 Receptor Alpha (IL2RA) Antibody (Biotin)
20-abx336176	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 2 Receptor Alpha (IL2Ra) Antibody (Biotin)
20-abx273269	Abbexa	EUR 560.40 EUR 292.80 EUR 1612.80 EUR 760.80 EUR 427.20	100 ug 10 ug 1 mg 200 ug 50 ug

Recombinant Interleukin 2 Receptor Alpha (IL2Ra)
4-RPB837Bo01	Cloud-Clone	EUR 646.85 EUR 296.40 EUR 2095.68 EUR 778.56 EUR 1437.12 EUR 508.80 EUR 5059.20	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Bovine Interleukin 2 Receptor Alpha expressed in: E.coli

Recombinant Interleukin 2 Receptor Alpha (IL2Ra)
4-RPB837Hu01	Cloud-Clone	EUR 582.34 EUR 279.60 EUR 1853.76 EUR 697.92 EUR 1275.84 EUR 465.60 EUR 4454.40	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Interleukin 2 Receptor Alpha expressed in: E.coli

Recombinant Interleukin 2 Receptor Alpha (IL2Ra)
4-RPB837Mu01	Cloud-Clone	EUR 614.59 EUR 288.00 EUR 1974.72 EUR 738.24 EUR 1356.48 EUR 487.20 EUR 4756.80	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Interleukin 2 Receptor Alpha expressed in: E.coli

Recombinant Interleukin 2 Receptor Alpha (IL2Ra)
4-RPB837Po01	Cloud-Clone	EUR 653.30 EUR 297.60 EUR 2119.87 EUR 786.62 EUR 1453.25 EUR 512.40 EUR 5119.68	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Pig Interleukin 2 Receptor Alpha expressed in: E.coli

Recombinant Interleukin 2 Receptor Alpha (IL2Ra)
4-RPB837Ra01	Cloud-Clone	EUR 657.60 EUR 300.00 EUR 2136.00 EUR 792.00 EUR 1464.00 EUR 516.00 EUR 5160.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Interleukin 2 Receptor Alpha expressed in: E.coli

Recombinant Interleukin 2 Receptor Alpha (IL2Ra)
4-RPB837Ra02	Cloud-Clone	EUR 657.60 EUR 300.00 EUR 2136.00 EUR 792.00 EUR 1464.00 EUR 516.00 EUR 5160.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Interleukin 2 Receptor Alpha expressed in: E.coli

Rat Interleukin 2 Receptor Alpha (IL2Ra) Protein
20-abx067495	Abbexa	EUR 910.80 EUR 360.00 EUR 2865.60 EUR 1095.60 EUR 644.40	100 ug 10 ug 1 mg 200 ug 50 ug

Pig Interleukin 2 Receptor Alpha (IL2Ra) Protein
20-abx168471	Abbexa	EUR 910.80 EUR 360.00 EUR 2848.80 EUR 1078.80 EUR 644.40	100 ug 10 ug 1 mg 200 ug 50 ug

Rat Interleukin 2 Receptor Alpha (IL2Ra) Protein
20-abx168561	Abbexa	EUR 910.80 EUR 360.00 EUR 2865.60 EUR 1095.60 EUR 644.40	100 ug 10 ug 1 mg 200 ug 50 ug

Cow Interleukin 2 Receptor Alpha (IL2Ra) Protein
20-abx166310	Abbexa	EUR 895.20 EUR 360.00 EUR 2815.20 EUR 1078.80 EUR 644.40	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody (HRP)
20-abx316446	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody (FITC)
20-abx316447	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Mouse Interleukin 2 Receptor Alpha (IL2Ra) Protein
20-abx067496	Abbexa	EUR 861.60 EUR 343.20 EUR 2665.20 EUR 1028.40 EUR 610.80	100 ug 10 ug 1 mg 200 ug 50 ug

Human Interleukin 2 Receptor Alpha (IL2Ra) Protein
20-abx067497	Abbexa	EUR 811.20 EUR 343.20 EUR 2498.40 EUR 961.20 EUR 577.20	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 2 Receptor Subunit Alpha (IL2RA) Antibody
20-abx159563	Abbexa	EUR 326.40 EUR 276.00	100 ug 50 ug

Interleukin 3 Receptor Alpha (IL3RA) Antibody
20-abx134363	Abbexa	EUR 427.20 EUR 678.00 EUR 360.00	100 ul 200 ul 50 ul

Interleukin 3 Receptor Alpha (IL3RA) Antibody
abx234277-100ug	Abbexa	100 ug	EUR 661.2

Interleukin 5 Receptor Alpha (IL5RA) Antibody
abx234280-100ug	Abbexa	100 ug	EUR 577.2

Interleukin 3 Receptor Alpha (IL3Ra) Antibody
20-abx103027	Abbexa	EUR 493.20 EUR 159.60 EUR 1378.80 EUR 678.00 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 3 Receptor Alpha (IL3Ra) Antibody
20-abx103028	Abbexa	EUR 510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 3 Receptor Alpha (IL3Ra) Antibody
20-abx103029	Abbexa	EUR 510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 5 Receptor Alpha (IL5Ra) Antibody
20-abx103030	Abbexa	EUR 493.20 EUR 159.60 EUR 1378.80 EUR 678.00 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 3 Receptor Alpha (IL3Ra) Antibody
20-abx173154	Abbexa	EUR 978.00 EUR 510.00	1 mg 200 ug

Interleukin 5 Receptor Alpha (IL5Ra) Antibody
20-abx173178	Abbexa	EUR 978.00 EUR 510.00	1 mg 200 ug

Interleukin 8 Receptor Alpha (IL8Ra) Antibody
20-abx173192	Abbexa	EUR 944.40 EUR 493.20	1 mg 200 ug

Interleukin 8 Receptor Alpha (IL8Ra) Antibody
20-abx173193	Abbexa	EUR 1011.60 EUR 526.80	1 mg 200 ug

Interleukin 8 Receptor Alpha (IL8Ra) Antibody
20-abx173194	Abbexa	EUR 1011.60 EUR 526.80	1 mg 200 ug

Interleukin 5 Receptor Alpha (IL5Ra) Antibody
20-abx177187	Abbexa	EUR 1412.40 EUR 693.60	1 mg 200 ug

Interleukin 8 Receptor Alpha (IL8Ra) Antibody
20-abx177202	Abbexa	EUR 1328.40 EUR 644.40	1 mg 200 ug

Interleukin 8 Receptor Alpha (IL8Ra) Antibody
20-abx177203	Abbexa	EUR 1362.00 EUR 661.20	1 mg 200 ug

Interleukin 8 Receptor Alpha (IL8Ra) Antibody
20-abx177204	Abbexa	EUR 1362.00 EUR 661.20	1 mg 200 ug

Interleukin 8 Receptor Alpha (IL8Ra) Antibody
20-abx177205	Abbexa	EUR 1412.40 EUR 693.60	1 mg 200 ug

Interleukin 3 Receptor Alpha (IL3RA) Antibody
20-abx213242	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Interleukin 3 Receptor Alpha (IL3RA) Antibody
20-abx210658	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Interleukin 5 Receptor Alpha (IL5RA) Antibody
20-abx211942	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Interleukin 5 Receptor Alpha (IL5RA) Antibody
20-abx211943	Abbexa	EUR 493.20 EUR 360.00	100 ul 50 ul

Interleukin 3 Receptor Alpha (IL3RA) Antibody
abx139575-01mg	Abbexa	0.1 mg	EUR 427.2

Interleukin 5 Receptor Alpha (IL5RA) Antibody
20-abx325299	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Interleukin 3 Receptor Alpha (IL3RA) Antibody
20-abx113253	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Interleukin 5 Receptor Alpha (IL5RA) Antibody
20-abx113255	Abbexa	EUR 878.40 EUR 477.60	150 ul 50 ul

Interleukin 5 Receptor Alpha (IL5RA) Antibody
abx030870-400ul	Abbexa	400 ul	EUR 627.6

Interleukin 5 Receptor Alpha (IL5RA) Antibody
abx030870-80l	Abbexa	80 µl	EUR 343.2

Interleukin 5 Receptor Alpha (IL5RA) Antibody
abx032450-400ul	Abbexa	400 ul	EUR 627.6

Interleukin 5 Receptor Alpha (IL5RA) Antibody
abx032450-80l	Abbexa	80 µl	EUR 343.2

Interleukin 3 Receptor Alpha (IL3RA) Antibody
abx015893-100ul	Abbexa	100 ul	EUR 493.2

Interleukin 3 Receptor Alpha (IL3RA) Antibody
abx015894-100ug	Abbexa	100 ug	EUR 493.2

Interleukin 3 Receptor Alpha (IL3RA) Antibody
abx034887-400ul	Abbexa	400 ul	EUR 627.6

Interleukin 3 Receptor Alpha (IL3RA) Antibody
abx034887-80l	Abbexa	80 µl	EUR 343.2

Interleukin 5 Receptor Alpha (IL5RA) Antibody
20-abx124275	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Interleukin 5 Receptor Alpha (IL5Ra) Antibody
20-abx129750	Abbexa	EUR 510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 3 Receptor Alpha (IL3RA) Antibody
20-abx323399	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Interleukin 5 Receptor Alpha (IL5RA) Antibody
20-abx323826	Abbexa	EUR 376.80 EUR 292.80	100 ug 50 ug

Interleukin 3 Receptor Alpha (IL3RA) Antibody
abx430549-200ul	Abbexa	200 ul	EUR 460.8

Interleukin 3 Receptor Alpha (IL3RA) Antibody
20-abx002867	Abbexa	EUR 493.20 EUR 710.40 EUR 218.40 EUR 376.80	100 ul 200 ul 20 ul 50 ul

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
20-abx134375	Abbexa	EUR 427.20 EUR 678.00 EUR 360.00	100 ul 200 ul 50 ul

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx200195-100ug	Abbexa	100 ug	EUR 393.6

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
20-abx200751	Abbexa	EUR 376.80 EUR 393.60	100 ug 500 ug

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx139566-01mg	Abbexa	0.1 mg	EUR 427.2

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx139567-01mg	Abbexa	0.1 mg	EUR 427.2

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
20-abx121575	Abbexa	EUR 360.00 EUR 526.80 EUR 226.80	100 ul 200 ul 30 ul

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx412774-01mg	Abbexa	0.1 mg	EUR 543.6

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx025269-100ul	Abbexa	100 ul	EUR 627.6

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx413741-02mg	Abbexa	0.2 mg	EUR 678

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx413847-01mg	Abbexa	0.1 mg	EUR 543.6

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx415231-01mg	Abbexa	0.1 mg	EUR 543.6

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx415240-01mg	Abbexa	0.1 mg	EUR 543.6

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx414178-01mg	Abbexa	0.1 mg	EUR 543.6

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx414536-05mg	Abbexa	0.5 mg	EUR 994.8

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx414537-01mg	Abbexa	0.1 mg	EUR 526.8

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx414539-025mg	Abbexa	0.25 mg	EUR 678

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx414966-1mg	Abbexa	1 mg	EUR 994.8

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx414967-01mg	Abbexa	0.1 mg	EUR 526.8

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx414968-1mg	Abbexa	1 mg	EUR 994.8

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx412877-025mg	Abbexa	0.25 mg	EUR 678

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx412878-01mg	Abbexa	0.1 mg	EUR 526.8

Interleukin-2 Receptor Subunit Alpha (CD25) Antibody
abx413298-01mg	Abbexa	0.1 mg	EUR 610.8

Cow Interleukin 2 Receptor Alpha (IL2Ra) CLIA Kit
20-abx493142	Abbexa	EUR 10282.80 EUR 5472.00 EUR 1262.40	10 × 96 tests 5 × 96 tests 96 tests

Rat Interleukin 2 Receptor Alpha (IL2Ra) CLIA Kit
20-abx493145	Abbexa	EUR 9567.60 EUR 5095.20 EUR 1177.20	10 × 96 tests 5 × 96 tests 96 tests

Interleukin 22 Receptor Alpha 2 (IL22RA2) Antibody (Biotin)
20-abx316448	Abbexa	EUR 493.20 EUR 2214.00 EUR 718.80 EUR 218.40 EUR 360.00	100 ug 1 mg 200 ug 20 ug 50 ug

Interleukin 13 Receptor Alpha 2 (IL13Ra2) Antibody (Biotin)
20-abx272541	Abbexa	EUR 526.80 EUR 292.80 EUR 1513.20 EUR 727.20 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 10 Receptor Alpha (IL10RA) Antibody
abx234213-100ug	Abbexa	100 ug	EUR 661.2

Interleukin 11 Receptor Alpha (IL11RA) Antibody
abx234217-100ug	Abbexa	100 ug	EUR 577.2

Interleukin 10 Receptor Alpha (IL10Ra) Antibody
20-abx103276	Abbexa	EUR 493.20 EUR 159.60 EUR 1378.80 EUR 678.00 EUR 376.80	100 ug 10 ug 1 mg 200 ug 50 ug

Interleukin 10 Receptor Alpha (IL10Ra) Antibody
20-abx103277	Abbexa	EUR 510.00 EUR 159.60 EUR 1412.40 EUR 693.60 EUR 393.60	100 ug 10 ug 1 mg 200 ug 50 ug

The study was conducted in normal mice cholangiocyte polarized monolayers, Mz-Cha-1 human bladder cells, and cholangiocytes isolated from murine liver tissue. The results showed that all models of bile reveal a complex receptor IL-4RA / IL-13Ra1.